On January 31, 1997, Schierholz, Joerg M.; Rump, Alexis; Pulverer, Gerhard published an article.Computed Properties of 86393-32-0 The title of the article was New antiinfectious biomaterials. Ciprofloxacin containing polyurethanes as potential drug delivery systems to prevent foreign-body infections. And the article contained the following:
Device related infections are an increasing problem since foreign materials are used in modern medicine. Ciprofloxacin-HCl salt (CAS 86393-32-0) and lipophilic ciprofloxacin-betaine (Bay o 9867) incorporated into polyurethanes by solvent casting technique were studied in order to develop antiinfectious properties of this biomaterial. Drug release rates, bacterial colonization and morphol. features of the polymer-ciprofloxacin combinations were studied and the physico-chem. mechanisms of the delivery were discussed. Ciprofloxacin salt showed a fast initial release rate, whereas ciprofloxacin-betaine was characterized by a more continuous release behavior. A higher diffusion of the lipophilic ciprofloxacin-betaine in the polymer could be shown as compared to its salt incorporated into the polyurethane. Bacterial colonization to the antibiotic-loaded polyurethanes was inhibited effectively only by preparations showing a slower but more sustained drug release. SEM demonstrated that the polyurethane-antibiotic combination was most homogeneous for ciprofloxacin-betaine. Polyurethane material loaded with ciprofloxacin salt showed crystals at the surface and a granular structure of the polymeric matrix. Crystalline structure of the drug on polymeric surfaces varied with loading concentration and lipophilicity. High homogeneity is required for a sustained and prolonged release and effective inhibition of bacterial colonization. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Computed Properties of 86393-32-0
The Article related to ciprofloxacin release polyurethane prosthetic, biomaterial polyurethane infection inhibition, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Computed Properties of 86393-32-0
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