On August 31, 2017, Le, Tien Canh published a patent.Formula: C17H21ClFN3O4 The title of the patent was Dual-rate release formulation with high drug loading comprising anionic polysaccharide amino acid complex, and preparation thereof. And the patent contained the following:
The present document describes a pharmaceutical excipient composition comprising a functionalized anionic polysaccharide having carboxyl groups complexed with an amino acid-divalent cation complex, monolithic solid dosage forms for dual rate release of an active pharmaceutical ingredient, comprising the pharmaceutical excipient composition and active pharmaceutical ingredients, as well as processes for preparing the pharmaceutical excipient composition The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Formula: C17H21ClFN3O4
The Article related to anionic polysaccharide amino acid complex dual rate pharmaceutical excipient, Pharmaceuticals: Formulation and Compounding and other aspects.Formula: C17H21ClFN3O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics