Huang, Jing; Huo, Hongqi; Lu, Rong published an article in 2022, the title of the article was A novel signature of necroptosis-associated genes as a potential prognostic tool for head and neck squamous cell carcinoma.Electric Literature of 380843-75-4 And the article contains the following content:
Head and neck squamous cell carcinoma (HNSCC) arises from squamous cells in the oral cavity, pharynx and larynx. Although HNSCC is sensitive to radiotherapy, patient prognosis is poor. Necroptosis is a novel programmed form of necrotic cell death. The prognostic value of necroptosis-associated gene expression in HNSCC has not been explored. We downloaded mRNA expression data of HNSCC patients from TCGA databases and Gene Expression Omnibus (GEO) databases, and compared gene expression between tumor tissues and adjacent normal tissues to identify differentially expressed genes (DEGs) and necroptosis-related prognostic genes. A model with necroptosis-related genes was established to predict patient prognosis via LASSO method and Kaplan-Meier anal. GSE65858 data set (n = 270) from GEO was used to verify the model’s predictive ability. Gene set enrichment analyses, immune microenvironment anal., principal component anal., and anti-tumor compound IC50 prediction were also performed. We identified 49 DEGs and found 10 DEGs were associated with patient survival (p < 0.05). A risk model of 6-gene signature was constructed using the TCGA training data set and further validated with the GEO data set. Patients in the low-risk group survived longer than those in the high-risk group (p < 0.05) in the GEO validation sets. Functional anal. showed the two patient groups were associated with distinct immunity conditions and IC50. We constructed a prognostic model with 6 necroptosis-associated genes for HNSCC. The model has potential usage to guide treatment because survival was different between the two groups. The experimental process involved the reaction of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile(cas: 380843-75-4).Electric Literature of 380843-75-4
The Article related to head and neck squamous cell carcinoma necroptosis prognosis, immune, necroptosis, prognosis, risk score, squamous cell carcinoma, tumor, Mammalian Pathological Biochemistry: Oncology and other aspects.Electric Literature of 380843-75-4
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