On January 18, 2022, Gao, Jing; Tan, Shaojie; Wang, Lu published a patent.Synthetic Route of 86393-32-0 The title of the patent was A kind of flexible fiber medicine box for intelligently releasing medicine and its preparation and application.. And the patent contained the following:
The invention relates to a flexible fiber medicine box for intelligently releasing medicine and its preparation and application. The preparation process of the medicine box is as follows: First, the porogen and the macromol. polymer are successively added to the organic solvent and after being mixed uniformly, the nanofiber membrane is prepared by electrospinning as a spinning solution The nanofiber membrane is then put into the Tris-hydrochloric acid buffer solution containing dopamine for modification treatment to obtain a polydopamine-modified nanofiber membrane. Then, the polydopamine-modified nanofiber membrane is placed in a mixed solution for grafting reaction to obtain a switch-loaded fiber membrane. Finally, the switch-loaded fiber membrane is washed and dried to obtain a flexible fiber medicine box. The kit includes porous fibers. PMAA is chem. grafted at the holes on the porous fibers. The prepared medicine box is loaded with medicine, and then the drug release test is carried out in the environment of pH 7.0 to 7.4, the medicine box will not release suddenly within the first 4 to 6 h, and the amount of drug release increases with the pH value of the drug release environment decreased and gradually increased. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Synthetic Route of 86393-32-0
The Article related to ciprofloxacin hydrochloride monohydrate dopamine polydopamine fiber medicine box electrospinning, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics