On October 15, 2022, Biyiklioglu, Zekeriya; Keles, Turgut; Sahin, Huseyin published an article.Electric Literature of 67914-60-7 The title of the article was Synthesis and acetylcholinesterase enzyme inhibition properties of axially disubstituted silicon phthalocyanines and their quaternized derivatives. And the article contained the following:
In this paper, axial 1,3-bis[4-(4-acetylpiperazin-1-yl)phenoxy]propanoxy and {2-[4-(4-acetylpiperazin-1-yl)phenoxy]ethoxy}ethoxy groups substituted silicon(IV) phthalocyanines PCSi(OR)2 [PP-D-Si, PP-OH2-Si; R = CH[CH2O-1,4-C6H4N(CH2CH2)2NCOMe]2, CH2CH2OCH2CH2O-1,4-C6H4N(CH2CH2)2NCOMe] and their quaternized derivatives (PP-D-SiQ, PP-OH2-SiQ) were synthesized and characterized. The acetylcholinesterase inhibition values of 1,3-bis[4-(4-acetylpiperazin-1-yl)phenoxy]propanoxy and {2-[4-(4-acetylpiperazin-1-yl)phenoxy]ethoxy}ethoxy groups substituted silicon(IV) phthalocyanines (PP-D-Si, PP-OH2-Si) and their quaternized derivatives (PP-D-SiQ, PP-OH2-SiQ) were measured by IC50 that reduces enzyme activity to 50% refers to the concentration of inhibitor. The synthesis compounds were classified as silicon and their quaternized derivatives and tagged as PP-D-Si, PP-OH2-Si, PP-D-SiQ and PP-OH2-SiQ. Except for the result of PP-D-SiQ was 1.586 ± 0.129μM, the results were expressed as mM ranged between 0.553 and 3.626 mM. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Electric Literature of 67914-60-7
The Article related to silicon phthalocyanine piperazine alkoxy derivative preparation cholinesterase inhibition, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Electric Literature of 67914-60-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics