Zhang, Lishun; Yang, Zichao; Sang, Huiting; Jiang, Ying; Zhou, Mingfeng; Huang, Chuan; Huang, Chunhui; Wu, Xiaoyun; Zhang, Tingting; Zhang, Xingmei; Wan, Shanhe; Zhang, Jiajie published an article in 2021, the title of the article was Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma.Recommanded Product: 380843-75-4 And the article contains the following content:
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in the central nervous system (CNS). As the ideal targets for GBM treatment, Src family kinases (SFKs) have attracted much attention. Herein, a new series of imidazo[4,5-c]pyridin-2-one derivatives were designed and synthesized as SFK inhibitors. Compounds , , , exhibited potential Src and Fyn kinase inhibition in the submicromolar range, of which were next tested for their antiproliferative potency on four GBM cell lines. Compound showed effective activity against U87, U251, T98G, and U87-EGFRvIII GBM cell lines, comparable to that of lead compound PP2. Mol. dynamics (MDs) simulation revealed the possible binding patterns of the most active compound in ATP binding site of SFKs. ADME prediction suggested that accord with the criteria of CNS drugs. These results led us to identify a novel SFK inhibitor as candidate for GBM treatment. The experimental process involved the reaction of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile(cas: 380843-75-4).Recommanded Product: 380843-75-4
The Article related to dasatinib anticancer agent glioblastoma, glioblastoma, src family kinase, imidazo[4,5-c]pyridin-2-one, kinase inhibitor, molecular simulation, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Recommanded Product: 380843-75-4
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