On January 31, 2022, Nakajima, Rui; Matsuo, Takuji; Sumiyoshi, Ritsu; Saito, Sumiko; Yamamoto, Tadashi; Matsumoto, Kensuke; Akiyama, Nobu; Ooi, Jun; Ota, Yasunori; Shirafuji, Naoki; Tashiro, Haruko published an article.Application In Synthesis of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile The title of the article was Extramedullary blast crisis in a chronic myeloid leukaemia patient after achieving a major molecular response with bosutinib. And the article contained the following:
FIrst report of an extramedullary blast crisis in the lymph nodes of a chronic myeloid leukemia (CML) patient on bosutinib. A 78-yr-old man was diagnosed with chronic phase (CP) CML in March 2015 and was treated with dasatinib 100 mg once daily as a first-line therapy. An excisional lymph node biopsy revealed the proliferation of blast cells with a starry-sky appearance. Bone marrow anal. did not indicate an increase in abnormal cells, and FISH anal. showed an absence of BCR-ABL1 fusion genes. From these findings, the patient was diagnosed with extramedullary B-lymphoid blast crisis that occurred in CP CML while under MMR. This case demonstrates the need to be mindful of the possibility of extramedullary disease even in patients having achieved MMR following TKI therapy. The experimental process involved the reaction of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile(cas: 380843-75-4).Application In Synthesis of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
The Article related to bosutinib antitumor chronic myeloid leukemia extramedullary blast crisis, cml, bosutinib, extramedullary, ponatinib, tyrosine kinase inhibitor, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Application In Synthesis of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
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