On August 24, 2007, Yagneskumar, Trivedi Amit; Pandurang, Gaitonde Shrikant; Anant, Shrikhande Atul; Pravichandra, Mehta Bharat published a patent.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Preparation methodology of piperazinylquinolones as antibacterial agents. And the patent contained the following:
The invention relates to the methodol. of reacting halogenated quinolinones with piperazine derivatives in a chem. system comprising of alkali salts of aromatic acids and a ternary mixture of (alkyl)pyridine, polar solvent represented by hydrophobic alkanols or DMSO, and N,N-dimethylglyoxime or biacetyl. Quinolinones reacted in this way with even equimolar of piperazines, good yields of the products were achieved. Another innovation is achieved by the use of moistured piperazines, including recycling of the unreacted piperazine solution in pyridine with substantial presence of water by adding dialkylsulfosuccinate , which has a surprisingly beneficial effect to the process. Example compound I•HCl•H2O (ciprofloxacin) was prepared by N-arylation of piperazine with 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to piperazinyl quinolone preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics