On June 30, 1985, Takeuchi, Isao; Sugiura, Michiharu; Yamamoto, Kazuko; Ito, Tomiyoshi; Hamada, Yoshiki published an article.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Syntheses and antimicrobial activities of cis-1-[2-phenyl-4-(phenoxy or phenylthio)methyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole derivatives. And the article contained the following:
Substitution reactions of glycerol ketals I (R, R1 = H, MeO; Br, Br; Cl, Cl) with heterocycles gave II (R2 = 1-imidazolyl, 1-pyrazolyl, 1,2,4-triazol-1-yl) which underwent successive saponification, mesylation, and substitution reaction with R3R4C6H3XH (R3, R4 = H, MeO, Cl, Me, Br; X = O, S) to give ketoconazole analogs III. Antimicrobial test of the synthesized compounds III (R2 = 1-imidazolyl; R, R1, R3, R4, X = Cl, Cl, H, 4-Cl, S; Cl, Cl, 2-Cl, 6-Cl, S; Br, Br, 2-Cl, 6-Cl, S) showed strong antimicrobial activities against Penicillium chrysogenum and Trichophyton rubrum. Most compounds synthesized had strong preventive effects against downy mildew and sheath blight. Triazole derivatives III (R2 = 1-triazolyl; R = R1 = Cl; R3 = H, 2-Cl; R4 = Cl; X = S, O) showed similar effects against not only such diseases but gray mold rot. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone
The Article related to ketoconazole analog preparation bactericide fungicide, dioxolanylmethylimidazole phenoxy phenylthio, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics