Mrachkovskaya, L. B.; Turchin, K. F.; Yakhontov, L. N. published an article in 1975, the title of the article was Reduction fragmentation of 4-methyl-1-piperazinylmethylidenemalonate.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride And the article contains the following content:
Di-Et 4-methyl-1-piperazinylmethylidenemalonate (I), prepared in 83.5% yield from 1-methylpiperazine (II) and EtOCH:C(CO2Et)2, was reductively cleaved by NaBH4 in absolute EtOH at 20-5° to give 65% of a mixture of II and methylmalonic acid (III). Analogous reduction in dioxane gave 11% II-III and in cyclohexane 5% II-III were obtained. Similar results were obtained by catalytic reduction with Pt. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride
The Article related to reduction cleavage piperazinylmethylenemalonic acid, pyruvoyl hydrazone reaction hydrazide, triazole acetyl anilino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics