Buhrmann, Mike; Wiedemann, Bianca M.; Muller, Matthias P.; Hardick, Julia; Ecke, Maria; Rauh, Daniel published an article in 2017, the title of the article was Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.COA of Formula: C13H16N2O2 And the article contains the following content:
In protein kinase research, identifying and addressing small mol. binding sites other than the highly conserved ATP-pocket are of intense interest because this line of investigation extends our understanding of kinase function beyond the catalytic phosphotransfer. Such alternative binding sites may be involved in altering the activation state through subtle conformational changes, control cellular enzyme localization, or in mediating and disrupting protein-protein interactions. Small organic mols. that target these less conserved regions might serve as tools for chem. biol. research and to probe alternative strategies in targeting protein kinases in disease settings. Here, the structure-based design and synthesis of a focused library of 2-arylquinazoline derivatives to target the lipophilic C-terminal binding pocket in p38α MAPK, for which a clear biol. function has yet to be identified is presented. The interactions of the ligands with p38α MAPK was analyzed by SPR measurements and validated by protein X-ray crystallog. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).COA of Formula: C13H16N2O2
The Article related to arylquinazoline preparation crystallization p38 map kinase ligand, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C13H16N2O2
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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics