On December 12, 2019, Beri, Aashima; Kaur, Rupinder; Banipal, Parampaul K.; Banipal, Tarlok S. published an article.Electric Literature of 86393-32-0 The title of the article was Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/L-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15-323.15 K and at Pressure p = 1 × 105 Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies. And the article contained the following:
Like the drug-salt interactions, drug-amino acid interaction in the aqueous medium is dependent upon different physiol. events occurring in the body. In this context, investigations on the interactions of ciprofloxacin hydrochloride (CFX) being a second-generation antibiotic with both nonessential amino acid and essential amino acid have been done. The physicochem. properties like apparent molar volume (V2,ϕ) and apparent molar isentropic compression (Ks,2,ϕ) of drug, CFX in water and in the presence of glycine (GLY), and L-isoleucine (ILU) at mB (molality of GLY or ILU) = 10, 20, 35, 50, and 75 mmol·kg-1 have been determined over the temperature range of 288.15-323.15 K and at p = 1 × 105 Pa. These data have further been used to calculate different parameters, which help to obtain valuable information corresponding to the distinct kinds of interactions present in the ternary systems. The volumes and compressibility studies have shown that the predominant interactions are hydrophilic-hydrophilic and hydrophilic-ionic in the studied systems. It may be postulated that the effect of CFX prevails through the hydrophilic groups of the constituents of proteins. Dehydration behavior of drug is also observed using hydration number and calorimetry at higher mB values. Both hyperchromic and hypsochromic changes have been observed from the absorption spectra for the CFX/ILU system. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0
The Article related to volumetric calorimetric property ciprofloxacin hydrochloride glycine isoleucine aqueous mixture, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Electric Literature of 86393-32-0
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