Month: October 2022

On June 10, 2021, Patwardhan, Neeraj Narendra; Chhabra, Milloni Balwantkumar; Hamilton, Gregory Lawrence; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa published a patent.Recommanded Product: 59695-29-3 The title of the patent was Preparation of lipid nanoparticles for nucleic acid delivery to immune cells. And the patent contained the following:

Lipid nanoparticle compositions comprising a conformationally constrained ionizable lipids useful for delivery of nucleic acids without the need for a targeting ligand are described. Compounds of formula I [wherein R1 = C9-20alkyl or C9-20alkenyl with 1-3 units of unsaturation; X1 and X2 independently = absent, -O-, NR2, -(CH)a-, wherein R2 is C1-6alkyl, and wherein X1 and X2 are not both -O- or NR2; a = integer between 1 and 6; X3 and X4 independently = (un)substituted 4- to 7-membered heterocyclyl or (un)substituted 5- to 6-membered heteroaryl; X5 = -(CH2)b-, wherein b = integer between 0 and 6; X6 = H, C1-6alkyl, (un)substituted 5- to 6-membered heteroaryl] and compositions thereof, are claimed and exemplified. Example compound II was prepared from a multistep process (preparation given). Prepared lipid nanoparticles in which siCD45 had been encapsulated were characterized using high throughput dynamic light scattering (data provided). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Recommanded Product: 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid deliver immune cell, sirna cd45 lipid nanoparticle encapsulation, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Recommanded Product: 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 15, 2014, Tang, Yan-feng; Mao, Jia-rong; Chen, Jiao; Sun, Tong-ming; Wang, Miao; Zhu, Jin-li published an article.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Synthesis of preladenant. And the article contained the following:

An intermediate, 1-(4′-methoxyethoxyl phenyl) piperazine (III), was synthesized from 1-(4′-hydroxylphenyl)-piperazinyl ethanone (I) via etherification and hydrolysis. Another intermediate (VII) with a nitrogen condensed ring was prepared from Me furan-2-carboxylate (IV) by acylation, ring-closure and halogenation. Finally, Preladenant was prepared from the two intermediates by condensation reaction. FTIR, 1HNMR and ESI-MS were employed to characterize these intermediates and the target compound Through common synthetic method, the yields of these 6 steps are 99.0%, 95.4%, 98.0%, 78.9%, 86.9% (calculated by Cl) and 52.5%, resp. To obtain a higher total yield, ultrasonic was used in the last condensation reaction. The results show that the condensation yield reached 85.4% when the reaction conditions were as follows: the ultrasonic power (150 W), the molar ratio of intermediate III to VII (1.2: 1), solvent (DMSO), acid-bonding agent (Na2CO3), reaction temperature (90°C) and reaction time (1.5 h). The yield of the condensation is greatly increased by ultrasonic method. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to preladenant condensation ultrasound, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 3, 2021, Zhao, Liang-Liang; Wu, Yixin; Huang, Shiqing; Zhang, Zengyu; Liu, Wei; Yan, Xiaoyu published an article.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Ortho-Selective Hydrogen Isotope Exchange of Phenols and Benzyl Alcohols by Mesoionic Carbene-Iridium Catalyst. And the article contained the following:

Hydrogen isotope exchange reactions of phenols and benzyl alcs. was achieved by a mesoionic carbene-iridium catalyst with high ortho selectivity and high functional group tolerance. Control experiments indicated that acetate is crucial to realize the ortho selectivity, whereas d. functional theory calculations supported an outer-sphere direction with hydrogen bonding between acetate and the hydroxyl group. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to phenol regioselective deuterium exchange, deuterated phenol preparation, benzyl alc regioselective deuterium exchange, deuterium benzyl alc preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2018, Amani, Ameneh; Nematollahi, Davood published an article.Product Details of 67914-60-7 The title of the article was One-pot electrochemical synthesis of highly symmetric and conjugated coumarin derivative. And the article contained the following:

A facile and one pot electrochem. synthesis of disubstituted hydroquinone generated from the electrochem. oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of 4-hydroxy-6,7-dimethylcoumarin was reported. The results revealed that p-quinone imine derived from oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone participated in Michael addition reactions with 4-hydroxy-6,7-dimethylcoumarin and followed by a hydrolysis reaction attain to the highly sym. and conjugated coumarin derivative A new product in good yield was derived based on controlled potential electrochem. oxidation at carbon electrode in a divided cell. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Product Details of 67914-60-7

The Article related to hydroxyphenyl piperazinyl ethanone hydroxy dimethylcoumarin one pot electrochem oxidation, dihydroxy phenylene bishydroxy dimethylchromenone preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Product Details of 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 5, 2018, Raajaraman, BR.; Sheela, N. R.; Muthu, S. published an article.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Investigation on 1-Acetyl-4-(4-hydroxyphenyl) piperazine an anti-fungal drug by spectroscopic, quantum chemical computations and molecular docking studies. And the article contained the following:

The title compound, 1-acetyl-4-(4-hydroxyphenyl)piperazine (1A4HP) has been examined by FT-Raman, FT-IR, 1HNMR, 13CNMR and UV-Visible spectra range. By using the d. functional theory (DFT) by the method B3LYP and basis set 6-311++G(d,p) the optimized figure of 1A4HP, the vibrational modes, the IR penetration intensities and the working of Raman scattering were estimated The optimized mol. figure obtained by the DFT method and its bond length and bond angle computed values are same as the XRD exptl. values. AIM topol. anal. was done on the mol. The HOMO and LUMO energy results show that good exchange of charge happened inside the mol. NBO method was applied to study donor-acceptor interactions. 1H and 13C chem. shift of NMR were estimated using the type gauge-independent AO (GIAO) and the results are related to the exptl. values. The hyperpolarizability computation shows the 1A4HP has very good NLO property. The anal. of Fukui function and Mol. electrostatic potential (MEP) studies were done. The essential thermodn. characters (entropy, enthalpy and heat capacity) of the 1A4HP estimated at various temperatures The best ligand-protein interactions are done by mol. docking with the various antifungal proteins and the ligand 1A4HP. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to acetyl hydroxyphenylpiperazine ir raman nlo property electrostatic potential, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 2, 2015, Salahifar, Eslam; Nematollahi, Davood; Bayat, Mehdi; Mahyari, Amir; Amiri Rudbari, Hadi published an article.Formula: C12H16N2O2 The title of the article was Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives. And the article contained the following:

A regioselective green synthesis of nitroacetaminophen derivatives e. g., I, was carried out by electrochem. oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochem. method for the synthesis of some nitroacetaminophen derivatives The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Formula: C12H16N2O2

The Article related to nitroacetaminophen derivative regioselective synthesis green chem, acetaminophen hydroxyphenylacetamide hydroxyphenylpiperazinylethanone electrochem oxidation nitrite ion and other aspects.Formula: C12H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 30, 2020, Bruemmendorf, Tim H.; Gambacorti-Passerini, Carlo; Bushmakin, Andrew G.; Cappelleri, Joseph C.; Viqueira, Andrea; Reisman, Arlene; Isfort, Susanne; Mamolo, Carla published an article.Formula: C26H29Cl2N5O3 The title of the article was Relationship between molecular response and quality of life with bosutinib or imatinib for chronic myeloid leukemia. And the article contained the following:

Abstract: Patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML) can be effectively treated with tyrosine kinase inhibitors (TKIs) and achieve a lifespan similar to the general population. The success of TKIs, however, requires long-term and sometimes lifelong treatment; thus, patient-assessed health-related quality of life (HRQoL) has become an increasingly important parameter for treatment selection. Bosutinib is a TKI approved for CP CML in newly diagnosed adults and in those resistant or intolerant to prior therapy. In the Bosutinib Trial in First-Line Chronic Myelogenous Leukemia Treatment (BFORE), bosutinib demonstrated a significantly higher major mol. response rate compared with imatinib, with maintenance of HRQoL (measured by the Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) questionnaire), after 12 mo of first-line treatment. We examined relationships between mol. response (MR) and HRQoL. MR values were represented by a log-reduction scale (MRLR; a continuous variable). A repeated-measures longitudinal model was used to estimate the relationships between MRLR as a predictor and each FACT-Leu domain as an outcome. Effect sizes were calculated to determine strength of effects and allow comparisons across domains. The majority of FACT-Leu domains (with the exception of social well-being and phys. well-being) demonstrated a significant relationship with MRLR (p < 0.05). Our results showed variable impact of clin. improvement on different dimensions of HRQoL. For patients who achieved MR5, emotional well-being and leukemia-specific domains showed the greatest improvement, with medium differences in effect sizes, whereas social well-being and phys. well-being had the weakest relationship with MR. The experimental process involved the reaction of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile(cas: 380843-75-4).Formula: C26H29Cl2N5O3

The Article related to bosutinib imatinib antileukemic agent diagnosis chronic myeloid leukemia, bosutinib, chronic myeloid leukemia, health-related quality of life, imatinib, molecular response and other aspects.Formula: C26H29Cl2N5O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2021, Nielsen, Soeren Saxmose; Bicout, Dominique Joseph; Calistri, Paolo; Canali, Elisabetta; Drewe, Julian Ashley; Garin-Bastuji, Bruno; Gonzales Rojas, Jose Luis; Gortazar Schmidt, Christian; Herskin, Mette; Michel, Virginie; Miranda Chueca, Miguel Angel; Padalino, Barbara; Pasquali, Paolo; Roberts, Helen Clare; Spoolder, Hans; Stahl, Karl; Velarde, Antonio; Viltrop, Arvo; Winckler, Christoph; Dewulf, Jeroen; Guardabassi, Luca; Hilbert, Friederike; Mader, Rodolphe; Baldinelli, Francesca; Alvarez, Julio published an article.Application of 86393-32-0 The title of the article was Assessment of animal diseases caused by bacteria resistant to antimicrobials: sheep and goats. And the article contained the following:

In this opinion, the antimicrobial-resistant bacteria responsible for transmissible diseases that constitute a threat to the health of sheep and goats have been assessed. The assessment has been performed following a methodol. based on information collected by an extensive literature review and expert judgement. Details of the methodol. used for this assessment are explained in a sep. opinion. A global state of play on antimicrobial resistance in clin. isolates of Staphylococcus aureus, Escherichia coli (non-VTEC), Pseudomonas aeruginosa, Dichelobacter nodosus, Moraxella ovis, Mannheimia haemolytica, Pasteurella multocida, Mycoplasma ovipneumoniae, Mycoplasma agalactiae, Trueperella pyogenes, Streptococcus uberis, Bibersteinia trehalosi, Campylobacter fetus, Mycoplasma mycoides subsp. capri, Mycoplasma capricolum subsp. capricolum, Fusobacterium necrophorum is provided. Among those bacteria, EFSA identified E. coli with > 66% certainty as being the most relevant antimicrobial-resistant bacteria in sheep and goat in the EU based on the available evidence. The animal health impact of these most relevant bacteria, as well as their eligibility for being listed and categorized within the animal health law framework will be assessed in sep. scientific opinions. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application of 86393-32-0

The Article related to animal diseases caused bacteria resistant antimicrobial sheep goat, animal health law, antimicrobial resistance, extensive literature review, goats, sheep, small ruminants and other aspects.Application of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 31, 2005, Rizk, N. M. H.; El-Kosasy, A. M. published an article.SDS of cas: 86393-32-0 The title of the article was Novel ciprofloxacin ion membrane sensors based on β-cyclodextrin. And the article contained the following:

Ciprofloxacin (CF) is sensitively detected in pharmaceuticals and human serum by potentiometric method. The proposed method based on the use of β-cyclodextrin (βCD) as ionophore, o-nitrophenyl octyl ether as plasticizer and potassium tetraphenyl-fluoromethylborate as a cationic additive, in polyvinyl chloride (PVC) matrix for the fabrication and construction of ciprofloxacin sensors. The conventional and microsized coated wire types are prepared, characterized compared and applied. The proposed sensors exhibit linear response in the range of 1×10-1-1×10-4 M ciprofloxacin with cationic slopes of 30.2±0.5 and 29.3±0.6 mV decade-1 at 25° over the pH range 4-6 for conventional and microsized coated wire, resp. Ciprofloxacin electrodes show reasonable selectivity towards some related compounds, amino acids, common organic and inorganic cations. The investigated procedures are successfully applied to the determination of ciprofloxacin in bulk powder, pharmaceutical products and human serum. Results with mean accuracy 99.8±0.6 % and 99.6±0.7 % for the nominal concentrations were obtained for conventional and microsized coated wire, resp., which compare well with data obtained using spectrophotometric (UV-Vis) method. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).SDS of cas: 86393-32-0

The Article related to ciprofloxacin sensor beta cyclodextrin ionophore potassium tetraphenyl fluoromethylborate, cationic additive pharmaceutical preparation nitrophenyl octyl ether plasticizer and other aspects.SDS of cas: 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 12, 1974, Jeanmart, Claude; Leger, Andre; Messer, Mayer N. published a patent.Recommanded Product: 4-Ethyl-piperazine-1-carbonyl chloride The title of the patent was [1,4]Dithiino[2,3-c]pyrrole derivatives. And the patent contained the following:

Dithiinopyrrolyl esters I (R =substituted 2-pyridyl, 2-naphthyridinyl, phenyl, 6-methoxy-3-pyridazinyl, 7-chloro-2-quinolyl, R1 = Me; R1 = Et, CHMe2, allyl, CH2CH2OH, R = 5-chloro-2-pyridyl) (25 compounds) were prepared by esterifying the alcs. II (R2 = OH, R3 = H), prepared by treating III with RNH2 and reducing II (R2R3 = O). Thus, 35. g III was treated with 24 g 2-amino-5-chloropyridine to give 51 g II (R = 5-chloro-2-pyridyl, R2R3 = O), which was reduced with KBH4 to 49.8 g II (R2 = OH, R3 = H). Esterification of 15 g of the alc. with 24.4 g 1-(chlorocarbonyl)-4-methylpiperazine gave 15.6 g I (R = 5-chloro-2-pyridyl, R1 = Me). I were tranquilizing, anticonvulsant, and muscle relaxant at 5-100 mg/kg orally in mice. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Recommanded Product: 4-Ethyl-piperazine-1-carbonyl chloride

The Article related to dithiinopyrrolyl ester, anticonvulsant dithiinopyrrolyl ester, muscle relaxant dithiinopyrrolyl ester, tranquilizer dithiinopyrrolyl ester, piperazine dithiinopyrrolyl ester and other aspects.Recommanded Product: 4-Ethyl-piperazine-1-carbonyl chloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics