Month: October 2022

Liao, Rong; Chang, Yan published the artcile< A study on N-Boc-2,2-dimethyl-piperazine>, Recommanded Product: 3,3-Dimethylpiperazin-2-one, the main research area is dimethylpiperazine synthesis.

This paper studies the reaction temperature, ratio of reactants, and catalyst in order to get N-Boc-2,2-dimethyl-piperazine, a synthesis of ethylenediamine, Et 2-bromoisobutyrate, and di-tert-Bu dicarbonate. Experiment results suggest that the optimal condition is: first, using ethylenediamine and Et 2-bromoisobutyrate with a ratio of 3:1 to get intermediate product under 70°C; and then using the potassium carbonate to catalyze the intermediate product to get the final product.

Sichuan Huagong published new progress about 22476-74-0. 22476-74-0 belongs to class piperazines, and the molecular formula is C6H12N2O, Recommanded Product: 3,3-Dimethylpiperazin-2-one.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Xie, Fuchun; Zhao, Hongbing; Li, Dewen; Chen, Hong; Quan, Haitian; Shi, Xiaojing; Lou, Liguang; Hu, Youhong published the artcile< Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors>, Product Details of C11H17BN2O2, the main research area is pyrimidine derivative preparation SAR tubulin polymerization inhibitor antiproliferative activity.

Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine I, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, I was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.

Journal of Medicinal Chemistry published new progress about Antimitotic agents. 229009-40-9 belongs to class piperazines, and the molecular formula is C11H17BN2O2, Product Details of C11H17BN2O2.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Khwaja, Sadiya; Fatima, Kaneez; Mishra, Divya; Babu, Vineet; Kumar, Yogesh; Malik, Sumera Banu; Tabassum, Misbah; Luqman, Suaib; Bawankule, Dnyaneshwar U.; Chanda, Debabrata; Khan, Feroz; Mondhe, Dilip M.; Negi, Arvind S. published the artcile< An improved synthesis of indanocine and antiproliferative activity of 2-benzylindanocine via microtubule destabilization>, Quality Control of 197638-83-8, the main research area is colon lung pancreatic cancer indanocine antiproliferative 2benzylindanocine microtubule destabilization; Ehrlich ascites carcinoma; acute oral toxicity; anticancer; antitubulin; indanocine.

Indanocine, a potent anticancer investigational drug of National Cancer Institute-USA, has been much discussed in recent years. Present communication aimed at total synthesis of indanocine and its close analogs. Total synthesis was improved by double yields than previously reported yields. Some of the benzylidene and 2-benzyl derivatives with free rotation at C2 position exhibited potential cytotoxicities against various human cancer cell lines. Five such analogs exhibited potential antiproliferative effect against HCT-116 and MIA PACA-2 cell lines. Benzylindanocine 12i induced microtubule destabilization by occupying colchicine binding pocket of β-tubulin. It also exhibited anti-inflammatory activity by down-regulating IL-6 and TNF-α. In Ehrlich ascites carcinoma model, 12i reduced 78.4% of EAC tumor in Swiss albino mice at 90 mg/kg (i.p.) dose. Further, in in vivo safety studies, 12i was found to be safe to rodents up to 1,000 mg/kg dose. Concomitant anticancer and anti-inflammatory activity of benzylindanocine is distinctive, which suggests its further optimization for better efficacy and druggability.

Chemical Biology & Drug Design published new progress about Antiproliferative agents. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Quality Control of 197638-83-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Jouffroy, Matthieu; Primer, David N.; Molander, Gary A. published the artcile< Base-Free Photoredox/Nickel Dual-Catalytic Cross-Coupling of Ammonium Alkylsilicates>, Computed Properties of 374930-88-8, the main research area is photoredox nickel catalyzed coupling ammonium alkylsilicate hetero aryl bromide.

Single-electron transmetalation is recognized as an enabling technol. for the mild transfer of alkyl groups to transition metal catalysts in cross-coupling reactions. Hypercoordinate silicates represent a new and improved class of radical precursors because of their low oxidation potentials and the innocuous byproducts generated upon oxidation Herein, authors report the cross-coupling of secondary and primary ammonium alkylsilicates with (hetero)aryl bromides in good to excellent yields. The base-free conditions have exceptional protic group tolerance on both partners, permitting the cross-coupling of unprotected primary and secondary amines.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent) (hetero). 374930-88-8 belongs to class piperazines, and the molecular formula is C13H19BrN4O2, Computed Properties of 374930-88-8.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

De-la-Torre, Pedro; Treuer, Adriana V.; Gutierrez, Margarita; Poblete, Horacio; Alzate-Morales, Jans H.; Trilleras, Jorge; Astudillo-Saavedra, Luis; Caballero, Julio published the artcile< Synthesis and in silico analysis of the quantitative structure-activity relationship of heteroaryl-acrylonitriles as AChE inhibitors>, Name: 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is AChE inhibitor antiAlzheimers agent mol docking QSAR Alzheimers disease.

Alzheimer disease (AD) is a neurodegenerative disorder that causes damages in brain due to factors such as oxidative stress, low-levels of the neurotransmitter acetylcholine, β-amyloid protein aggregation, etc. It is necessary the design of novel efficient drugs for AD treatment to counteract the increase of people suffering from AD. Recently, heteroaryl-acrylonitrile derivatives have emerged as a new family of acetylcholinesterase inhibitors (AChEIs). The anal. of the structure-activity relationship of these compounds could help to elucidate the main mol. features that contribute to the activity of these compounds In this paper, we performed 3D-QSAR analyses through a Comparative Similarity Indexes Anal. (CoMSIA) to determine the key-factors for the activity of E/Z-heteroaryl-acrylonitriles reported in literature and novel derivatives that are reported in this work for the first time. The novel derivatives were synthesized in order to enlarge the library of compounds available in literature. They were synthesized via microwave-assisted Knoevenagel reaction and their biol. activities as AChE/BuChE inhibitors were explored by the Ellman’s spectrophotometric method. The best CoMSIA model included both electrostatic and hydrogen bond donor fields (CoMSIA-ED model) and provided the best statistical results with a highest Q2 value of 0.901. The model also had satisfactory predictions of external compounds Our in silico study provided a new tool for predicting the affinity of heteroaryl-acrylonitriles as AChEIs to the scientific community. It can be used for guiding the design and synthesis of novel, selective, and more potent AChEIs.

Journal of the Taiwan Institute of Chemical Engineers published new progress about Alzheimer disease. 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Name: 1-Boc-4-(4-Formylphenyl)piperazine.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Li, Xu; Chen, Xiaolan; Yuan, Jinwei; Qu, Lingbo; Zhu, Haisheng; Bi, Wenzhu; Zhao, Yufen published the artcile< Synthesis and Characterization of Phosphoramide Piperazine Analogs of Paeonol>, COA of Formula: C9H19ClN2O2, the main research area is phosphoramide piperazine analog paeonol preparation.

Based on the phosphorylated reaction, an efficient general synthetic approach that provide facile, rapid and cheap access to a wide range of novel phosphoramide derivatives of paeonol has been developed. These analogs of paeonol are synthesized in high yields and elucidated by IR, HR MS, and NMR.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Phosphoramides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, COA of Formula: C9H19ClN2O2.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Polo, Efrain; Ferrer-Pertuz, Karoll; Trilleras, Jorge; Quiroga, Jairo; Gutierrez, Margarita published the artcile< Microwave-assisted one-pot synthesis in water of carbonylpyrazolo[3,4-b]pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety>, Name: 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is arylidene pyrazoloquinolinone preparation diastereoselective; pyrazolopyridinyl chalcone preparation diastereoselective; pyrazolopyridine green preparation aldehyde Claisen Schmidt base catalyst ultrasound; aminopyrazole formaldehyde beta diketone domino condensation indium catalyst microwave.

An efficient method was developed for the synthesis of pyrazolo[3,4-b]pyridine derivatives, e.g., I, via In-catalyzed one-pot three-component condensation of 3-methyl-1-phenyl-1H-pyrazolo-5-amine, formaldehyde (as paraformaldehyde) and β-diketones under microwave irradiation in aqueous media. This process had advantages of simple operation, higher yields, low cost and environmentally benign procedure. Further sonochem.-assisted Claisen-Schmidt condensation of pyrazolopyridines I with aryl aldehydes under basic catalysis afforded arylidene-pyrazolo[3,4-b]quinolinones II [RR1 = (CH2)2; Ar = Ph, 4-MeOC6H4, 1-methylimidazol-2-yl, etc.] and pyrazolo[3,4-b]pyridinyl chalcones II [R = H, R1 = Me].

RSC Advances published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Name: 1-Boc-4-(4-Formylphenyl)piperazine.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Sung, Dan-Bi; Mun, Bohyun; Park, Sol; Lee, Hyi-Seung; Lee, Jihoon; Lee, Yeon-Ju; Shin, Hee Jae; Lee, Jong Seok published the artcile< Synthesis, Molecular Engineering, and Photophysical Properties of Fluorescent Thieno[3,2-b]pyridine-5(4H)-ones>, Formula: C11H17BN2O2, the main research area is thienopyridinone synthesis regioselective aza cycloaddition aminothiophene unsaturated carboxylic acid; fluorescent thienopyridinone synthesis.

We describe a synthetic approach for a set of fluorescent thieno[3,2-b]pyridine-5(4H)-one derivatives and their photophys. properties. These fluorophores are prepared by a series of reactions employing the Suzuki-Miyaura cross-coupling reaction and a regioselective aza-[3 + 3] cycloaddition of 3-aminothiophenes with α,β-unsaturated carboxylic acids. Our findings revealed that the photophys. properties are chem. tunable by an appropriate choice of functional group on the thieno[3,2-b]pyridine-5(4H)-one scaffold.

Journal of Organic Chemistry published new progress about [3+3] Cycloaddition reaction (regioselective aza-[3 + 3] cycloaddition). 229009-40-9 belongs to class piperazines, and the molecular formula is C11H17BN2O2, Formula: C11H17BN2O2.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Rudolf, Klaus; Eberlein, Wolfgang; Engel, Wolfhard; Pieper, Helmut; Entzeroth, Michael; Hallermayer, Gerhard; Doods, Henri published the artcile< Development of Human Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists. Potent and Selective Small Molecule CGRP Antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)piperazine: The First CGRP Antagonist for Clinical Trials in Acute Migraine>, Computed Properties of 76535-74-5, the main research area is oxoquinazolinpiperazine derivative preparation CGRP receptor antagonist antimigraine migraine.

Although the triptans have greatly improved the acute treatment of migraine headache, there are yet many shortcomings. Therefore, new strategies for the treatment of migraine are needed which offer advantages over current therapy, e.g. triptans. Our novel approach was based on the hypothesis that the release of calcitonin gene-related peptide (CGRP) could play a causative role in migraine headache. Thus the authors initiated a program aimed at the design and synthesis of small mol. CGRP receptor antagonists. High throughput screening led to the identification of (R)-Tyr-(S)-Lys dipeptide-like compounds that showed weak but unequivocal binding to the human CGRP receptor. Lead optimization afforded highly potent CGRP antagonists, the prototype being compound (I) (BIBN4096). This compound exhibiting a favorable biol. profile was selected for initial clin. trials. A proof of concept study indicated that i.v. application of I was effective in the treatment of acute migraine headache. This finding strongly supports our initial working hypothesis that CGRP plays an important role in the pathophysiol. of migraine.

Journal of Medicinal Chemistry published new progress about Antimigraine agents. 76535-74-5 belongs to class piperazines, and the molecular formula is C9H19ClN2O2, Computed Properties of 76535-74-5.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Donnell, Andrew F.; Zhang, Yong; Stang, Erik M.; Wei, Donna D.; Tebben, Andrew J.; Perez, Heidi L.; Schroeder, Gretchen M.; Pan, Chin; Rao, Chetana; Borzilleri, Robert M.; Vite, Gregory D.; Gangwar, Sanjeev published the artcile< Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads>, Electric Literature of 229009-40-9, the main research area is macrocyclic pyrrolo benzodiazepine dimer preparation antibody drug conjugate mesothelin; Antibody-drug conjugates; Macrocycles; Pyrrolobenzodiazepines.

Macrocyclic pyrrolobenzodiazepine dimers were designed and evaluated for use as antibody-drug conjugate payloads. Initial structure-activity exploration established that macrocyclization could increase the potency of PBD dimers compared with non-macrocyclic analogs. Further optimization overcame activity-limiting solubility issues, leading to compounds with highly potent (picomolar) activity against several cancer cell lines. High levels of in vitro potency and specificity were demonstrated with an anti-mesothelin conjugate.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 229009-40-9 belongs to class piperazines, and the molecular formula is C11H17BN2O2, Electric Literature of 229009-40-9.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics