On February 29, 2008, Zhao, Lihua; Liu, Chaomei; Wu, Qiuye; Zhang, Lurong; Kim, Joanne published an article.SDS of cas: 67914-60-7 The title of the article was Design, synthesis and antitumor activity of thalidomide derivatives. And the article contained the following:
The antitumor activity of thalidomide derivatives [i.e., 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione derivatives] was studied. A method for the synthesis of the title compounds is reported here. According to the structure of thalidomide, starting from β-D-glucosamine hydrochloride, twenty compounds were designed and synthesized. Product structures were determined by NMR, IR, MS. The target compounds were evaluated for their anticancer activity. The survival of 4T1 cells was determined Compounds substituted by a 3,4,6-tri-O-acetyl glucopyranoside have better antitumor activity than thalidomide dose. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).SDS of cas: 67914-60-7
The Article related to thalidomide analog glucopyranoside preparation antitumor agent breast cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 67914-60-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics