On July 29, 2022, Zhang, Chen; Wang, Jianmin; Qian, Guofei; Huang, Zhenggang; Tang, Pingming; Ye, Fei; Li, Yao; Ni, Jia; Yan, Pangke published a patent.Application of 1211568-27-2 The title of the patent was Preparation of a bifunctional molecule with EGFR degradation as antitumor agent. And the patent contained the following:
The present invention discloses a preparation of a bifunctional mol. with EGFR degradation as antitumor agent, which can be used to prepare drugs for treating diseases related to EGFR activity. The invention compound was prepared via the reaction of benzyl piperazine-1-carboxylate and tert-Bu 3-oxoazetidine-1-carboxylate, followed by deprotection, condensation, reduction reaction and substitution reaction. The experimental process involved the reaction of tert-Butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate(cas: 1211568-27-2).Application of 1211568-27-2
The Article related to preparation egfr degradation antitumor agent condensation suzuki coupling, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 1211568-27-2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics