On April 30, 2007, He, Qiu Qin; Liu, Chao Mei; Li, Ke; Cao, Yong Bing published an article.Category: piperazines The title of the article was Design, synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus. And the article contained the following:
Based on the active site of Aspergillus fumigatus lanosterol 14α-demethylase (AF-CYP51), novel triazole compounds I (R = aryl) were designed. Their chem. synthesis and the antifungal activities were reported. The results showed that all the target compounds exhibited excellent activities with broad spectrum, in which I (R = 4-FC6H4, 4-H2NCOC6H4, pyridin-4-yl) showed comparable activities against A. fumigatus to the control drug Itraconazole. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Category: piperazines
The Article related to piperazinyl triazole preparation antifungal aspergillus fumigatus, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics