On January 1, 2014, Cremonesi, Giuseppe; Dalla Croce, Piero; La Rosa, Concetta published an article.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Lewis acid-catalyzed formylation reaction of 4-(piperazin-1-yl)phenols. And the article contained the following:
The Lewis acid-catalyzed reaction of 4-(piperazin-1-yl)phenols I (R1 = Ac, CHO, Boc, PhCH2; R2 = H) with paraformaldehyde in aprotic solvents afforded salicylaldehydes I (R2 = CHO) in good yields. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone
The Article related to salicylaldehyde piperazinyl preparation, phenol piperazinyl paraformaldehyde formylation lewis acid catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics