On July 14, 2011, Aissaoui, Hamed; Boss, Christoph; Corminboeuf, Olivier; Heidmann, Bibia; Siegrist, Romain published a patent.Quality Control of 4-(4-Acetylpiperazin-1-yl)benzaldehyde The title of the patent was Preparation of piperazines as antimalarial agents. And the patent contained the following:
The invention relates to piperazine derivatives of Formula I (wherein X is CH or N; R1 is -NO2, -NMe2, H, CN, etc.; and R2 is H, Me, CN, halo, etc.), and their use as active ingredients in the preparation of pharmaceutical compositions The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting the corresponding cinnamic acid derivative with amine intermediate III, was very effective in both in vivo and in vitro antimalarial assays. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).Quality Control of 4-(4-Acetylpiperazin-1-yl)benzaldehyde
The Article related to piperazine compound preparation antimalarial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 4-(4-Acetylpiperazin-1-yl)benzaldehyde
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics