On August 24, 2016, Li, Qingshan; Zhang, Yuanlin; Feng, Xiue published a patent.Formula: C7H13ClN2O The title of the patent was Preparation of N-formyloxy substituted chlorobenzophenone derivatives. And the patent contained the following:
The invention discloses structure construction of N-formyloxy substituted chlorobenzophenone novel derivative I; in its structure R is N-formyl group; wherein two hydrogen atoms on nitrogen atom are substituted by two same straight-chain alkyls or branched alkyls with carbon atom of 1-4, or two hydrogen atoms on nitrogen atom are substituted to generate pyrrole ring, piperazine ring, piperidine ring, morpholine ring. Meanwhile, the invention discloses application of the N-formyloxy substituted chlorobenzophenone novel derivative and its pharmaceutical salts in preparing medicines for cardiovascular disease caused by vascular endothelial cell injury. The N-formyloxy substituted chlorobenzophenone derivative of the invention can remarkably improve protection activity to H2O2 induced vascular endothelial cell injury, and it has important application prospect in preparing related medicine for preventing or treating cardiovascular disease caused by vascular endothelial cell injury. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Formula: C7H13ClN2O
The Article related to preparation formyloxy substituted chlorobenzophenone derivative, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Formula: C7H13ClN2O
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics