On April 11, 2013, Letavic, Michael A.; Lord, Brian; Bischoff, Francois; Hawryluk, Natalie A.; Pieters, Serge; Rech, Jason C.; Sales, Zachary; Velter, Adriana I.; Ao, Hong; Bonaventure, Pascal; Contreras, Victor; Jiang, Xiaohui; Morton, Kirsten L.; Scott, Brian; Wang, Qi; Wickenden, Alan D.; Carruthers, Nicholas I.; Bhattacharya, Anindya published an article.Related Products of 1428327-31-4 The title of the article was Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists. And the article contained the following:
The synthesis and preclin. characterization of two novel, brain penetrating P2X7 compounds will be described. Both compounds are shown to be high potency P2X7 antagonists in human, rat, and mouse cell lines and both were shown to have high brain concentrations and robust receptor occupancy in rat. Compound I is of particular interest as a probe compound for the preclin. assessment of P2X7 blockade in animal models of neuro-inflammation. The experimental process involved the reaction of N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide(cas: 1428327-31-4).Related Products of 1428327-31-4
The Article related to brain penetrating p2x7 antagonist nicotinamide isoquinolinecarboxamide derivative, p2x7, depression, neuro-inflammation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 1428327-31-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics