On July 15, 2021, Hamilton, Gregory Lawrence; Patwardhan, Neeraj Narendra; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa; Chhabra, Milloni Balwantkumar published a patent.Application of 59695-29-3 The title of the patent was Preparation of lipid nanoparticle compositions for delivery of nucleic acids to cells. And the patent contained the following:
Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the formula I [R1 = alkyl, alkenyl; X1, X2 = O, (substituted) NH, alkylene, etc.; X3, X4 = heterocyclyl, heteroaryl, aryl, cycloalkyl, etc.; X5 = absent, alkyl, alkylene; X6 = H, alkyl, heteroaryl, heterocyclyl, etc.; A1, A2 = haloalkyl, alkenyl, etc.; n = 1-4]. Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Application of 59695-29-3
The Article related to lipid nanoparticle preparation nucleic acid delivery, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Application of 59695-29-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics