On April 14, 1994, Bourzat, Jean Dominique; Commercon, Alain published a patent.Formula: C8H18Cl2N2O2 The title of the patent was Preparation of taxol analogs as antiproliferatives. And the patent contained the following:
Title compounds [I; R1 = (cyclo)alkyl, aryl, heterocyclyl, etc.; R2 = aminohydroxypropionyl group Q; R = Ph, OR6; R3 = aryl; R6 = (cyclo)alk(en)yl, Ph, N-containing heterocyclyl, etc.] were prepared as antiproliferatives (no data). Thus, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α,10β-trihydroxy-9-oxo-7β-triethylsilyloxy-11-taxene was acylated by 3-morpholinopropionic acid and the product acylated by (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid to give, in 2 addnl. steps, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-10β-(3-morpholinopropionyloxy)-9-oxo-11-taxen-13α-yl (2R,3S)-3-tert-butyloxy-2-hydroxy-3-phenylpropionate. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2
The Article related to taxol analog preparation antiproliferative, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Formula: C8H18Cl2N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics