On June 30, 2013, Shou, Kai-jun; Li, Jie; Jin, Yi; Lv, Yan-wen published an article.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Design, synthesis, biological evaluation, and molecular docking studies of quinolone derivatives as potential antitumor topoisomerase I inhibitors. And the article contained the following:
A novel series of quinolone derivatives were designed and synthesized, and their biol. activities were evaluated as potential antitumor topoisomerase I (Top I) inhibitors. Among these compounds, one compound exhibited the most potent antitumor activities against multiple cancer cell lines. Docking simulation was performed to insert compound this compound into the crystal structure of DNA-Top I to determine the probable binding model. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to phenylsulfonyl carbamidoyl quinolone preparation topoisomerase inhibitor structure activity relationship, topoisomerase phenylsulfonyl carbamidoyl quinolone docking antitumor drug design and other aspects.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics