Wambua, Victor; Hirschi, Jennifer S.; Vetticatt, Mathew J. published an article in 2021. The article was titled 《Rapid Evaluation of the Mechanism of Buchwald-Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects》, and you may find the article in ACS Catalysis.Formula: C5H12N2 The information in the text is summarized as follows:
A practical approach is introduced for the rapid determination of 13C kinetic isotope effects that utilizes a “”designed”” reactant with two identical reaction sites. The mechanism of the Buchwald-Hartwig amination of tert-butylbromobenzene with primary and secondary amines is investigated under synthetically relevant catalytic conditions using traditional intermol. 13C NMR methodol. at natural abundance. Switching to 1,4-dibromobenzene, a sym. bromoarene as the designed reactant, the same exptl. 13C KIEs are determined using an intramol. KIE approach. This rapid methodol. for KIE determination requires substantially less material and time compared to traditional approaches. Details of the Buchwald-Hartwig amination mechanism are investigated under varying synthetic conditions, namely a variety of halides and bases. The enantioselectivity-determining step of the L-proline catalyzed aldol reaction is also evaluated using this approach. We expect this mechanistic methodol. to gain traction among synthetic chemists as a practical technique to rapidly obtain high-resolution information regarding the transition structure of synthetically relevant reactions under catalytic conditions. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Formula: C5H12N2)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Formula: C5H12N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics