Computed Properties of C5H12N2In 2020 ,《Design, synthesis, antimicrobial activity and molecular docking studies of some novel di-substituted sulfonylquinoxaline derivatives》 was published in Bioorganic Chemistry. The article was written by Ammar, Yousry A.; Farag, Awatef A.; Ali, Abeer M.; Ragab, Ahmed; Askar, Ahmed A.; Elsisi, Doaa M.; Belal, Amany. The article contains the following contents:
Compound I [R = Cl] was prepared via reaction of o-phenylene diamine with oxalic acid followed by chlorosulfonation with excess chlorosulfonic acid. A series of new sulfonylquinoxaline derivatives I [R = 3-MeOC6H4, 1-piperidyl, 2-(cyanomethyl)benzimidazol-1-yl, etc.] were obtained upon reacting compound I [R = Cl] with different types of amines. Compound II [R1 = R2 = Cl] was reacted with different secondary amines yielded mono and di secondary aminoquinoxaline derivatives II [R1 = 1-piperidyl, 4-methylpiperazin-1-yl, morpholino; R2 = Cl, morpholino, NHNH2, etc.] depending on the reactivity difference of the two chlorine atoms. Hydrazinolysis of compound II [R1 = 1-piperidyl, 4-methylpiperazin-1-yl, morpholino; R2 = Cl] furnished hydrazino quinoxaline derivatives II [R1 = 1-piperidyl, 4-methylpiperazin-1-yl, morpholino; R2 = NHNH2]. Addnl. triazolo and pyrazolyl quinoxaline derivatives III and IV [R3 = 5-OH-3-Me-pyrazol-1-yl, 2-[(2,5-diphenylpyrazol-3-yl)methylene]hydrazino] were obtained through the reaction of compound II [R1 = 1-piperidyl; R2 = NHNH2] with Ph isothiocyanate, formylpyrazole and Et acetoacetate. All the synthesized compounds were screened for their antibacterial and antifungal activities. Compounds II [R1 = 1-piperidyl, R2 = Cl; R1 = R2 = 4-methylpiperazin-1-yl; R1 = 1-piperidyl, R2 = 4-methylpiperazin-1-yl; R1 = 4-methylpiperazin-1-yl, R2 = 1-piperidyl; R1 = morpholino, R2 = 4-methylpiperazin-1-yl; R1 = morpholino, R2 = NHNH2] showed good to moderate antimicrobial activity against the tested Gram-pos., Gram-neg. bacteria and fungi with MIC values ranging from 2.44 to 180.14μM. Their MBC values were also evaluated using the same tested microorganisms. Moreover, screening against multi-drug resistant strains revealed the promiscuity of these new derivatives, especially compound II [R1 = 1-piperidyl, R2 = Cl] that showed comparable antibacterial activity (MIC 4.91-9.82μM) with Norfloxacin (MIC 2.44-9.80μM). Furthermore, these compounds were evaluated as DNA Gyrase inhibitors and the obtained results were in the range of 15.69-23.72μM. Mol. docking studies of the promising derivatives into DNA Gyrase binding site proved the usefulness of hybridizing quinoxaline scaffold with SO2 and morpholine moieties as a hopeful strategy in designing new DNA Gyrase binding mols. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Computed Properties of C5H12N2)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Computed Properties of C5H12N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics