In 2022,Yamaguchi, Nobuharu; Biniecki, Kristof; Jankowski, Christopher K.; Ciszewski, Lech published an article in Acta Poloniae Pharmaceutica. The title of the article was 《Cardiovascular evaluation of the chemical structure of N-methylpiperazinyl phthalazine analogs》.Product Details of 109-01-3 The author mentioned the following in the article:
The chem. structure of N-methylpiperazinyl phthalazine analogs – KB compounds, having potential cardiovascular effects, were synthesized and its detailed spectral identification is reported. For KB-1, moiety structure, five physiol. cardiovascular tests were performed and the results were discussed. This mol. showed long-lasting antihypertensive properties with similarly long-lasting bradycardia. However, a slight modification of the mol. structure might minimize the cardiac depressant phenomenon, which is a common undesired effect of various antihypertensive drugs on the market. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics