Wang, Xintong; Xiao, Haoran; Wang, Jing; Huang, Zongze; Peng, Geng; Xie, Wenjun; Bian, Xiling; Liu, Huijie; Shi, Cheng; Yang, Taoyi; Li, Xin; Gao, Jian; Meng, Ying; Jiang, Qianchen; Chen, Wei; Hu, Fang; Wei, Ningning; Wang, Xiaowei; Zhang, Liangren; Wang, KeWei; Sun, Qi published an article in 2021. The article was titled 《Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors》, and you may find the article in Journal of Medicinal Chemistry.Reference of 1-Methylpiperazine The information in the text is summarized as follows:
The design, synthesis, and evaluation of N-(4-(trifluoromethoxy)phenyl)-1,3,5-triazin-2-amine derivatives I [R = 4-Me, 4-F, 3,4-di-F, etc.], II [R1 = 4-Me, 4-MeO, 4-F3C, 4-F3CO, 3-F3CO; R2 = 4-F, 4-MeO, 4-Cl, etc.] and III [R3 = Me, methylamino, prop-1-ynyl, etc.] as a series of novel α7 nAChR pos. allosteric modulators (PAMs). The representative compound III [R3 = methylamino] functioned as a type I PAM with an EC50 of 3.0μM and approx. 38-fold enhancement of α7 current in the presence of agonist acetylcholine (100μM). It specifically enhanced α7 current with high selectivity. Compound III [R3 = methylamino] showed good pharmacokinetic property in mice. I.p. injection of III [R3 = methylamino] (3 mg/kg) exhibited sufficient blood-brain barrier penetration in mice. Furthermore, III [R3 = methylamino] were also rescued the auditory gating deficit in mice with schizophrenia-like behavior. Mol. docking of III [R3 = methylamino] with homopentameric α7 nAChR reveald a new mode of action. These results supported the potential of III [R3 = methylamino] for treatment for schizophrenia and Alzheimer’s disease. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3Reference of 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Reference of 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics