In 2022,Venkatesh, Rapelly; Shankar, Gauri; Narayanan, Aswathi C.; Modi, Gyan; Sabiah, Shahulhameed; Kandasamy, Jeyakumar published an article in Journal of Organic Chemistry. The title of the article was 《Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease》.Product Details of 109-01-3 The author mentioned the following in the article:
Multicomponent synthesis of biol. relevant S-benzyl dithiocarbamates I [Ar = Ph, 2-thienyl, 2-naphthyl, etc.; R = methylamino, 1-pyrrolidinyl, benzylamino, etc.] from para-quinone methides, amines and carbon disulfide were described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, compound I [Ar = Ph, R = isopropylamino] showed considerable acetylcholinesterase (AChE) inhibitory (51.70 + 5.63% at 20μm) and antioxidant (63.52 ± 1.15 at 20μm) activities. In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3) was used in this study.
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics