In 2019,Chemistry & Biology Interface included an article by Ismail, Pathan Sultan; Khan, Irfan; Kumar, Vivek; Verma, Ved Prakash; Shukla, Monika; Dhasmana, Anupam; Pandey, Shashi; Singh, Girdhar Pal; Khan, Shahnawaz; Singh, Jaybir. Recommanded Product: 1-Methylpiperazine. The article was titled 《Synthesis and biological evaluation of 2,4-diaminopyrimidine-5-carbonitrile and N-(2-amino-5-cyanopyrimidin-4-yl)benzamide derivatives as EGFR inhibitors》. The information in the text is summarized as follows:
A series of 2,4-diaminopyrimidine-5-carbonitriles and N-(2-amino-5-cyanopyrimidin-4-yl)benzamides I and II [R = 1-piperidyl, 1-morpholinyl, 4-methylpiperazin-1-yl, 4-benzylpiperazin-1-yl, 4-(2-methoxyphenyl)piperazin-1-yl] were synthesized and their chem. structures were confirmed by 1H, 13C NMR and mass spectral data. Anticancer activity of all the synthesized compounds I and II were evaluated for in-vitro cytotoxic activity against a panel of four human cancer cell lines i.e., human breast (MCF-7), cervical cancer (C33A), oral (KB) and prostrate (DU-145). All the examined compounds, I and II demonstrated potent to moderate anticancer activity. Among all the synthesized compounds, I [ R = 1-(2-methoxyphenyl)piperazinyl] and II [R1 = 1-(2-methoxyphenyl)piperazinyl] exhibited more potent activity. Docking studies for I [ R = 1-(2-methoxyphenyl)piperazinyl] and II [R1 = 1-(2-methoxyphenyl)piperazinyl] into EGFR active site was carried out to investigate their potential binding modes. Therefore, compounds I [ R = 1-(2-methoxyphenyl)piperazinyl] and II [R1 = 1-(2-methoxyphenyl)piperazinyl] was considered as fascinating candidates for further expansion of more potent anticancer agents. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics