The author of 《Anticancer activities of novel Mannich bases against prostate cancer cells》 were Demirci, Serpil; Demirbas, Neslihan. And the article was published in Medicinal Chemistry Research in 2019. Product Details of 109-01-3 The author mentioned the following in the article:
This study was designed to synthesize hybridizing mols. starting from compound of 6-(4-phenyl-piperazin-1-yl)pyridine-3-ylamine by enhancing its biol. activity with other heterocycles and to determine anticancer activity of the resulting compounds To this end, 6-(4-phenylpiperazin-1-yl)pyridin-3-ylamine was used as the leading compound, which was known to exert anticancer activities. The synthesis of the leading compound was carried out using 1-(5-nitropyridin-2-yl)-4-phenylpiperazine which was obtained by a novel method with the reaction of N-phenylpiperazine and 2-chloro-5-nitropyridine. 6-(4-Phenylpiperazin-1-yl)pyridin-3-ylamine was converted to ester compound, an active intermediate compound, by substitution of one of the amine hydrogens with Et bromoacetate. The resulting ester product followed by the hydrazidation was added arylisocyanate to obtain the active intermediate. Then, by a series of substitution through cyclization and condensation reactions, thiazolidinone, 1,3,4-oxadiazole and 1,2,4-triazole were synthesized. Novel Mannich bases were obtained using oxazole and triazole hetero rings with primer or secondary amine compounds The characterization of the compounds was completed using FT IR, 1H-NMR, 13C-NMR, HRMS spectroscopic methods and elemental anal. technique. The chems., then, were tested for their anticancer activities against prostate cancer cell lines PC3 [ATCC, CRL-1435], LNCaP [ATCC, CRL-1740] and DU145 [ATCC, HTB-81]. The results revealed that the Mannich bases exhibited moderate cytotoxic activity against cancer cells tested. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics