Application In Synthesis of 1-MethylpiperazineIn 2020 ,《Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS》 was published in Bioorganic Chemistry. The article was written by Abdellatif, Khaled R. A.; Belal, Amany; El-Saadi, Mohamed T.; Amin, Noha H.; Said, Eman G.; Hemeda, Loah R.. The article contains the following contents:
A new series of benzothiazoles hybridized with a pyrimidine moiety, e.g., I (R = Cl), was designed and synthesized using the lead compound II (R1 = Ph). Various chem. modifications on the pyrimidine ring of II (R1 = Ph) at four different positions were done in a trial to get new multi-targeted anticancer agents. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data. All final synthesized derivatives were submitted to the National Cancer Institute (NCI), USA, to be screened for their in vitro anticancer activity. Further evaluation for the cytotoxic activity of the most active compounds was performed using the MTT assay method. Compounds I [R = (4-acetylphenyl)amino, morpholin-4-yl, 4-methylpiperazin-1-yl], II (R1 = 4-oxo-4H-chromen-3-yl), and III were then selected for examination of their in vitro inhibitory activities against EGFR, HER2 and TS enzymes using lapatinib and 5FU as standards Furthermore, cell cycle anal. and apoptosis induction detection were also evaluated. Finally, mol. docking studies were carried out for compounds I [R = (4-acetylphenyl)amino, morpholin-4-yl, 4-methylpiperazin-1-yl], II (R1 = 4-oxo-4H-chromen-3-yl), and III to interpret their observed enzymic activities based on the ligand-protein interactions. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3Application In Synthesis of 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application In Synthesis of 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics