Scapecchi, Serena; Martini, Elisabetta; Manetti, Dina; Ghelardini, Carla; Martelli, Cecilia; Dei, Silvia; Galeotti, Nicoletta; Guandalini, Luca; Romanelli, Maria Novella; Teodori, Elisabetta published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs》.Safety of 1-(Isopropylsulfonyl)piperazine The author mentioned the following in the article:
Structure-activity relationships on two novel potent cognition enhancing drugs, unifiram and sunifiram, are reported. Although none of the compounds synthesized reached the potency of the parent drugs, some fairly active compounds have been identified that may represent new leads to develop other cognition enhancing drugs. An interesting result of this research is the identification of two compounds that are endowed with amnesing activity (the opposite of the activity of the original mols.) and are nearly equipotent to scopolamine. Moreover, two other compounds of the series were found endowed with analgesic activity on a rat model of neuropathic pain at the dose of 1 mg/kg. In the experimental materials used by the author, we found 1-(Isopropylsulfonyl)piperazine(cas: 534615-34-4Safety of 1-(Isopropylsulfonyl)piperazine)
1-(Isopropylsulfonyl)piperazine(cas: 534615-34-4) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.Safety of 1-(Isopropylsulfonyl)piperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics