《Triphenylethylene analogues: Design, synthesis and evaluation of antitumor activity and topoisomerase inhibitors》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Rani, Sudesh; Paul, Kamaldeep. SDS of cas: 109-01-3 The article mentions the following:
To structurally relate anticancer drug tamoxifen used in the treatment of breast cancer, a sequence of compounds I [R = piperidinyl, morpholino, 4-methylpiperazinyl, 4-ethylpiperazinyl, etc.] were designed and synthesized as potential drug candidates. McMurry coupling reaction was used as the key synthetic step in the preparation of these compounds I and the ratios of E/Z-isomers were determined on the basis of NMR and HPLC experiments The new compounds I were found to be cytotoxic in the micromolar range with 60 human tumor cell lines at one dose and five dose concentration levels. Detailed studies on the most active compounds I [R = 2-morpholinoethyl amine, cyclohexylamine and diethylamine] show these compounds were capable to inhibit the growth of cancer cells. Finally, with the aim to correlate the antiproliferative activity with an intracellular target(s), the effect on relaxation activity of DNA topoisomerase-II was assayed. The relevance of interaction of most active compounds with topoisomerase-II was demonstrated which was also supported by docking studies. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3SDS of cas: 109-01-3)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..SDS of cas: 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics