Nishiguchi, Gisele A.; Atallah, Gordana; Bellamacina, Cornelia; Burger, Matthew T.; Ding, Yu; Feucht, Paul H.; Garcia, Pablo D.; Han, Woo-Seok; Klivansky, Liana; Lindvall, Mika published the artcile< Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases>, Recommanded Product: 1-Boc-4-(4-Formylphenyl)piperazine, the main research area is indole pyrazolopyridine derivative preparation SAR Pim kinase inhibitory.
A series of novel 3,5-disubstituted indole e. g., I and pyrazolopyridine e. g., II derivatives as potent and selective inhibitors of all three members of the Pim kinase family is described. High throughput screen identified a pan-Pim kinase inhibitor with a promiscuous scaffold. Guided by structure-based drug design, SAR of the series afforded a highly selective indole chemotype that was further developed into a potent set of compounds against Pim-1, 2, and 3 (Pim-1 and Pim-3: IC50 ≤ 2 nM and Pim-2: IC50 ≤ 100 nM).
Bioorganic & Medicinal Chemistry Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 197638-83-8 belongs to class piperazines, and the molecular formula is C16H22N2O3, Recommanded Product: 1-Boc-4-(4-Formylphenyl)piperazine.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics