In 1993,Bulletin of the Faculty of Pharmacy (Cairo University) included an article by Al-Deeb, O. A.; Al-Rashood, K. A.; Khalil, A. A.. Product Details of 34352-59-5. The article was titled 《Synthesis of new (1-phenylcyclohexyl)piperazine derivatives as potential analgesics》. The information in the text is summarized as follows:
A series of phencyclidine isostere derivatives was prepared by replacement of the piperidine ring by N-substituted piperazines. The Strecker synthesis was employed for synthesis of the intermediate carbonitriles I [R = (un)substituted Ph, Me, PhCH2; R1 = CN]. The synthesis of the target compounds I (same R; R1 = Ph) was accomplished by treatment of the carbonitrile with phenylmagnesium bromide. These compounds were tested for analgesic activity, but none were effective. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Product Details of 34352-59-5)
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Product Details of 34352-59-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics