Yang, Yang; Niedermann, Katrin; Han, Chong; Buchwald, Stephen L. published the artcile< Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides>, Category: piperazines, the main research area is secondary alkylzinc Negishi coupling heteroaryl halide palladium biarylphosphine catalyst.
The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described [e.g., using a palladacycle precatalyst ligated by CPhos, 3-chlorobenzisothiazole was coupled with i-PrZnBr.LiCl to afford 3-isopropylbenzisothiazole in 78% yield (normal:rearranged ratio = 98:2)]. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates. Preparation and characterization of oxidative addition complex (L)(Ar)PdBr provided insight into the unique reactivity of catalysts based on CPhos-type ligands in facilitating challenging reductive elimination processes.
Organic Letters published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl halides → sec-alkyl heteroaryl compounds). 374930-88-8 belongs to class piperazines, and the molecular formula is C13H19BrN4O2, Category: piperazines.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics