Ruby, Philip R.; De Benneville, Peter L. published the artcile< Leuckart alkylation of 2-piperazinones>, Recommanded Product: 3,3-Dimethylpiperazin-2-one, the main research area is .
The availability of 2-piperazinones suggested alkylation on the amine N, thereby leaving the amide N free for methylolation without side reactions. The reaction proceeded smoothly at 100-30° to give good yields when aldehydes were used but ketones did not react even at higher temperatures and 4-formyl-2-piperazinone, m. 170-2°, was the only product. In the sequence, NH3, MeNH2, and Me2NH, yields of 78, 53, and 0% were obtained in the Leuckart reaction with laurophenone (Crossley and Moore, C.A. 39, 1147.5). 3,3-Dimethyl-2-piperazinone (I) (128 g.) and 35 g. paraformaldehyde at reflux treated dropwise with 57.5 g. HCO2H, the mixture heated 2.5 hrs. on the steam bath and distilled yielded 131 g. 3,3,4-trimethyl-2-piperazinone, m. 131-2°. Paraldehyde (9.7 g.), 25.6 g. I, and 11.5 g. HCO2H heated 29 hrs. at 125-30° yielded 27% 3,3-dimethyl-4-ethyl-2-piperazinone, m. 164-5°. I (51.2 g.), 62 g. p-ClC6H4CHO, and 23 g. HCO2H refluxed 8 hrs. yielded 53 g. 3,3-dimethyl-4-p-chlorobenzyl-2-piperazinone, m. 201-3°. For other 4-substituted compounds, substituent, crude yield (%), and m.p. (uncorrected) are: iso-Bu, 60, 136-8°; 3,4-methylenedioxybenzyl, 35, 190-3°; 3,5,5-trimethylhexyl, 73, 99-100°.
Journal of the American Chemical Society published new progress about Aldehydes. 22476-74-0 belongs to class piperazines, and the molecular formula is C6H12N2O, Recommanded Product: 3,3-Dimethylpiperazin-2-one.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics