Synthetic Route of C5H12N2In 2020 ,《Solvent free synthesis of three cyclotriphosphazene derivatives containing piperazine substituents using microwave irradiation. Spectral, theoretical, solution and docking studies》 was published in Phosphorus, Sulfur and Silicon and the Related Elements. The article was written by Hakimi, Mohammad; Rezaei, Homeyra; Moeini, Keyvan; Mardani, Zahra; Carpenter-Warren, Cameron. The article contains the following contents:
Three new cyclotriphosphazene-based compounds, 2,2,4,4,6,6-hexakis(4-R-piperazin-1-yl)-1,3,5,2λ5,4λ5,6λ5-cyclotriazatriphosphinine (1-3; R = Me, Et, Ph), were prepared and identified by elemental anal., FT-IR, Raman as well as 1H and 31P NMR spectroscopy. The redox properties of the compounds were investigated by cyclic voltammetry. The predicted structures and charge distribution patterns of the compounds were obtained by DFT calculations and NBO anal. The geometrical parameters in these optimized structures are in good agreement with the average values obtained for analogs from the CSD database. The theor. studies confirm presence of a strong resonance in the cyclotriphosphazene ring. Finally, the ability of the three new derivatives to interact with ten selected biomacromols. (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS, Top II, B-DNA) was investigated by docking calculations and compared with that of doxorubicin. In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Synthetic Route of C5H12N2) was used in this study.
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Synthetic Route of C5H12N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics