Month: September 2022

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. SDS of cas: 103-76-4.

Lei, Hongrui;Guo, Ming;Li, Xiaopeng;Jia, Fang;Li, Changtao;Yang, Yu;Cao, Meng;Jiang, Nan;Ma, Enlong;Zhai, Xin research published 《 Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great In Vivo Efficacy in a Mouse Lung Fibrosis Model》, the research content is summarized as follows. Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). There is great interest in developing nonacidic ATX inhibitors with a specific binding mode to serve as potential in vivo effective therapeutic tools. Herein, dating from a high-throughput screening (HTS) product Indole-1 (740 nM), a dedicated optimization campaign was implemented through derivatizing the -COOH group to versatile linkers that well-bridged the indole skeleton and the hydrophobic pocket binding groups. Ultimately, it was established that the coexistence of a carbamate linker and -OH-group-containing amines could generally furnish excellent indole-based ATX inhibitors with even below 1 nM in vitro activities. Two optimal entities were advanced to a bleomycin-induced mice pulmonary fibrosis model, which exerted promising efficacy in alleviating the damaged lung texture caused by bleomycin exposure. The novel carbamate-containing indole-based ATX inhibitors with a concrete binding mode may contribute to the identification of potential therapeutic agents to intervene in fibrotic diseases.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, SDS of cas: 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Application In Synthesis of 103-76-4.

Lei, Hongrui;Li, Changtao;Yang, Yu;Jia, Fang;Guo, Ming;Zhu, Minglin;Jiang, Nan;Zhai, Xin research published 《 Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects》, the research content is summarized as follows. ATX was capable of catalyzing the hydrolysis of LPC to the lipid mediator LPA which attracted considerable attention on the development of potent ATX inhibitors. Herein, driven by the HTS product indole-based lead 1, a hybridization strategy was utilized to construct the trifluoroacetyl hydrazone moiety through assembling the Ph thiazole fragment to the indole skeleton of lead 1. After a systematic structure guided optimization, by cycling the Ph thiazole to the compacted benzothiazole or decreasing the lipophilicity, two promising ATX inhibitors (9j(I) and 25a(II)) were identified with IC₅₀ values of 2.1 nM and 19.0 nM, resp. All compounds were tested a panel of cancer cell lines and a preliminary affinity on breast cancer cell lines (SI > 16.5) were observed which shed a light on their potential application of breast cancer relevant cases. Through a dedicated docking study, the intramol. pseudo-ring within the trifluoroacetylhydrazone moiety played a significant role in constraining the binding poses of 9j and 25a. Finally, a binding free energy calculation was conducted to examine the contribution of different interactions in binding affinity.

Application In Synthesis of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Electric Literature of 103-76-4.

Lei, Hongrui;Li, Zhen;Li, Tong;Wu, Huinan;Yang, Jing;Yang, Xinlian;Yang, Yu;Jiang, Nan;Zhai, Xin research published 《 Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model》, the research content is summarized as follows. Aiming to develop novel allosteric autotaxin (ATX) inhibitors, hybrid strategy was utilized by assembling the benzyl carbamate fragment in PF-8380 onto the imidazo[1,2-a]pyridines I (R = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 4-(trifluoromethyl)phenyl, 2H-1,3-benzodioxol-5-yl, R¹ = pyrrolidin-1-yl, morpholin-4-yl, 4-methylpiperazin-1-yl, etc.; R² = Me, Et) skeleton of GLPG-1690. The piperazine moiety in GLPG-1690 was replaced with Ph ring to enhance the π-π interactions with adjacent residues. In the light of FS-3 based ATX enzymic assay, further structure-guided optimizations were implemented by exploring the substituents within the carbamate aromatic moiety and examining the effect of the 2-Et. Eventually, I (R = 2H-1,3-benzodioxol-5-yl; R¹ = 4-(2-hydroxyethyl)piperazin-1-yl; R² = Et) (II) bearing 1,3-benzodioxole and 2-hydroxyethyl piperazine group was identified as a powerful ATX inhibitor with an IC₅₀ value of 2.7 nM. Subsequently, compound II was forwarded into an in vivo bleomycin-induced mice lung fibrosis model. In histopathol. and immunohistochem. assays, compound II could typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA. At a dose of 60 mg/kg, compound II was observed equivalent or even better potency than GLPG-1690 with a significant inhibition of the in vivo ATX activity. Except for the fundamental H-bond and π-π interactions, an extra H-bond between the 1,3-benzodioxole (O atom) and Phe306 offered great rationale in constraining the binding conformation of compound II. Finally, binding free energy calculation was conducted to assist in the efficient identification of allosteric ATX inhibitors.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Electric Literature of 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Recommanded Product: N-(2-Hydroxyethyl)piperazine.

Lefranc, Julien;Schulze, Volker Klaus;Hillig, Roman Christian;Briem, Hans;Prinz, Florian;Mengel, Anne;Heinrich, Tobias;Balint, Jozsef;Rengachari, Srinivasan;Irlbacher, Horst;Stoeckigt, Detlef;Boemer, Ulf;Bader, Benjamin;Gradl, Stefan Nikolaus;Nising, Carl Friedrich;von Nussbaum, Franz;Mumberg, Dominik;Panne, Daniel;Wengner, Antje Margret research published 《 Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor》, the research content is summarized as follows. The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homolog IKKε are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and, in particular, in inflammation. Herein, we describe our investigations on a family of benzimidazoles and the identification of the potent and highly selective TBK1/IKKε inhibitor BAY-985. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Recommanded Product: N-(2-Hydroxyethyl)piperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Recommanded Product: N-(2-Hydroxyethyl)piperazine.

Lee, Byung Joo;Ickes, Andrew R.;Gupta, Anil K.;Ensign, Seth C.;Ho, Tam D.;Tarasewicz, Anika;Vanable, Evan P.;Kortman, Gregory D.;Hull, Kami L. research published 《 Synthesis of Unsymmetrical Vicinal Diamines via Directed Hydroamination》, the research content is summarized as follows. The rhodium-catalyzed hydroamination of primary and secondary allylic amines using diverse amine nucleophiles, including primary, secondary, acyclic, and cyclic aliphatic amines to access a wide range of unsym. vicinal diamines, was presented. The utility of this methodol. was further demonstrated through the rapid synthesis of several bioactive mols. and analogs.

Recommanded Product: N-(2-Hydroxyethyl)piperazine, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Formula: C6H14N2O.

Leal, Emilse S.;Adler, Natalia S.;Fernandez, Gabriela A.;Gebhard, Leopoldo G.;Battini, Leandro;Aucar, Maria G.;Videla, Mariela;Monge, Maria Eugenia;Hernandez de los Rios, Alejandro;Acosta Davila, John Alejandro;Morell, Maria L.;Cordo, Sandra M.;Garcia, Cybele C.;Gamarnik, Andrea V.;Cavasotto, Claudio N.;Bollini, Mariela research published 《 De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus》, the research content is summarized as follows. Dengue fever is a mosquito-borne viral disease that has become a major public health concern worldwide. This disease presents with a wide range of clin. manifestations, from a mild cold-like illness to the more serious hemorrhagic dengue fever and dengue shock syndrome. Currently, neither an approved drug nor an effective vaccine for the treatment are available to fight the disease. The envelope protein (E) is a major component of the virion surface. This protein plays a key role during the viral entry process, constituting an attractive target for the development of antiviral drugs. The crystal structure of the E protein reveals the existence of a hydrophobic pocket occupied by the detergent n-octyl-β-d-glucoside (β-OG). This pocket lies at the hinge region between domains I and II and is important for the low pH-triggered conformational rearrangement required for the fusion of the virion with the host’s cell. Aiming at the design of novel mols. which bind to E and act as virus entry inhibitors, we undertook a de novo design approach by “growing” mols. inside the hydrophobic site (β-OG). From more than 240000 small-mols. generated, the 2,4 pyrimidine scaffold was selected as the best candidate, from which one synthesized compound displayed micromolar activity. Mol. dynamics-based optimization was performed on this hit, and thirty derivatives were designed in silico, synthesized and evaluated on their capacity to inhibit dengue virus entry into the host cell. Four compounds were found to be potent antiviral compounds in the low-micromolar range. The assessment of drug-like physicochem. and in vitro pharmacokinetic properties revealed that compounds 3e and 3h presented acceptable solubility values and were stable in mouse plasma, simulated gastric fluid, simulated intestinal fluid, and phosphate buffered saline solution pyrimidine.

Formula: C6H14N2O, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. SDS of cas: 103-76-4.

Kuroda, Shoichi;Kobashi, Yohei;Kawamura, Madoka;Kawabe, Kenichi;Shiozawa, Fumiyasu;Hamada, Makoto;Shimizu, Yuki;Okumura-Kitajima, Lisa;Koretsune, Hiroko;Kimura, Kayo;Yamamoto, Koji;Kakinuma, Hiroyuki research published 《 Synthesis and structure-activity relationship of C-phenyl D-glucitol (TP0454614) derivatives as selective sodium-dependent glucose cotransporter 1 (SGLT1) inhibitors》, the research content is summarized as follows. Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from the gastrointestinal tract. While C-Ph d-glucitol derivative SGL5213 has been reported to be a potent intestinal SGLT1 inhibitor for use in the treatment of type 2 diabetes, no SGLT1 selectivity was found in vitro (IC50 29 nM for hSGLT1 and 20 nM for hSGLT2). In this study we found a new method of synthesizing key intermediates 12 by a one-pot three-component condensation reaction and discovered C-Ph d-glucitol 41j (TP0454614), which has >40-fold SGLT1 selectivity in vitro (IC₅₀ 26 nM for hSGLT1 and 1101 nM for hSGLT2). The results of our study have provided new insights into the structure-activity relationships (SARs) of the SGLT1 selectivity of C-glucitol derivatives

SDS of cas: 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Recommanded Product: N-(2-Hydroxyethyl)piperazine.

Kucukdumlu, Asligul;Tuncbilek, Meral;Guven, Ebru Bilget;Atalay, Rengul Cetin research published 《 Design, synthesis and in vitro cytotoxic activity of new 6,9-disubstituted purine analogues》, the research content is summarized as follows. A series of new 6,9-disubstituted purine analogs I [R = cyclohexyl, Ph, 4-CF₃C₆H₄, etc., R¹ = Cl, CF₃] with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds I were screened initially for their in vitro anticancer activity on Huh7 liver, HCT116 colon and MCF7 breast carcinoma cell lines. Cytotoxic bioactivity studies revealed that all compounds I screened, with compound I [R = pyrimidine-2-yl, R¹ = Cl] being the exception, were found to have promising cytotoxic activities at IC₅₀ range of 0.05-21.8μM against cancer cells Huh7, HCT116 and MCF7. Among the prepared purine analogs, two of them (compounds I [R = 4-CF₃C₆H₄, R¹ = Cl, CF₃]) exhibited excellent cytotoxic activities, with IC₅₀ 0.08-0.13μM, on Huh7 cells comparable to camptothecin (CPT) and better than cladribine, fludarabine and 5-FU. Afterwards, the evaluation of cytotoxicity of the most potent purine analogs was screened against further hepatocellular cancer (HCC) cell lines. The compounds I [R = 4-CF₃C₆H₄, R¹ = CF₃; R = 3,4-Cl₂C₆H₃, R¹ = Cl] displayed a significant IC₅₀ values (IC₅₀ < 0.1-0.13μM) comparable to CPT and better cytotoxic bioactivity when compared with 5-FU, cladribine and fludarabine on HCC cells (Huh7 and HepG2).

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Recommanded Product: N-(2-Hydroxyethyl)piperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Application In Synthesis of 103-76-4.

Khan, Azam;Hayat, Faisal;Butler, Ian S.;Nawaz Tahir, Muhammad;ur Rehman, Zia research published 《 Mercury(II) dithiocarbamates: Structural aspects and their use as single-source precursors for shape-controlled facile synthesis of HgS nanoparticles》, the research content is summarized as follows. A single-source, precursor strategy has been adopted for the shape-controlled synthesis of HgS nanoparticles (NPs) in which Hg(II) dithiocarbamate complexes are used as the starting materials. The precursor complexes bis(4-benzhydrylpiperazine-1-carbodithioate-κ² S,S’)mercury(II), bis(4-benzylpiperazine-1-carbodithioate-κ² S,S’)mercury(II), bis(4-hydroyethylpiperazine-1-carbodithioate-κ² S,S’)mercury(II), bis(4-benzylpiperidine-1-carbodithioate-κ² S,S’)mercury(II) and propane-1,3-diyl-bis(piperidincarbamodithioate)mercury(II), termed as [Hg(L1)₂] to [Hg(L5)₂] resp., were characterized by chem. anal. (CHNS), FT-IR, ¹H and ¹³C NMR spectroscopy. Two of the complexes, [Hg(L1)₂] and [Hg(L2)₂], were also subjected to single-crystal XRD anal. to recognize their mol. and supramol. features. The conversion of the precursor complexes to HgS NPs was achieved by their thermolysis in ethylenediamine (en) at ambient pressure and low temperature in the absence of any externally added toxic surfactant. The morphol., structure, phase and elemental composition of the resulting HgS NPs were analyzed by SEM, PXRD and EDS techniques. The SEM results revealed a significant precursor-based morphol. variation in the HgS NPs, which could be attributed to the stability/solubility of the initial precursor complex in ethylenediamine and to the presence of a capping agent on the particle surfaces (as revealed by DFT studies and FT-IR anal.). The PXRD patterns showed that the HgS NPs grow in two typical cystalline forms – cubic (black) and hexagonal (red). The optical properties of the NPs were assessed by UV-Visible spectroscopy, which confirmed that they have a good absorption ability in the visible region.

Application In Synthesis of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Product Details of C6H14N2O.

Katiyar, Jyoti Devi;Chattopadhyay, Subrata research published 《 Quantitative functionalization of chitosan using green and efficient azetidinium-amine reactions》, the research content is summarized as follows. Despite significant advances in the field, quant. post-polymer modification of chitosan, specifically attaching diverse hydrophobic moieties with exptl. predefined (via the ratio of reagents) degree of functionalization remain extremely challenging. In this context, we report our studies toward the use of green and efficient azetidinium-amine reactions to prepare a library of modified chitosan with a predefined degree of functionalization, with excellent conversion (>90%), atom economy and very low E-factor (<0.1). Initially six different azetidinium functionalized coupler mols., which contains azetidinium functionality attached with other defined target functionality (ranging from hydrophobic to hydrophilic) are synthesized. In the next stage the azetidinium functionalized coupler mols. are reacted with chitosan (both low mol. weight and high mol. weight chitosans are used) in presence of 1,4-diazabicyclo[2.2.2]octane(DABCO, as base) using water as solvent and the other functional moiety are attached with the chitosan backbones. The degree of functionalization was calculated using ¹H NMR and excellent match (80-100%) was noted between calculated degree of functionalization and feed ratio of the reagents used (exptl. defined ratio).

Product Details of C6H14N2O, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics