Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Safety of N-(2-Hydroxyethyl)piperazine.
Yin, Yong;Zhou, Yang;Sha, Shao;Wu, Xun;Wang, She-Feng;Qiao, Fang;Song, Zhong-Cheng;Zhu, Hai-Liang research published 《 Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα》, the research content is summarized as follows. A series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates I [R = piperidin-1-ylmethyl, piperazin-1-ylmethyl, 4-benzhydrylpiperazin-1-ylmethyl, etc.] containing piperazine were synthesized. They were evaluated for their PI3Kα wild-type and H1047R mutant inhibitory activities and anticancer effects in-vitro. Most of these compounds displayed the potential antiproliferative activities against four cancer cell lines (HCT-116, A549, Huh7 and HL60). Among them, compound I [R = 4-benzhydrylpiperazin-1-ylmethyl] revealed the remarkable antiproliferative activity and was selected for further biol. evaluation. Compound I [R = 4-benzhydrylpiperazin-1-ylmethyl] displayed the potent activity against both PI3Kα wild-type and H1047R mutant, and a certain degree of selectivity for PI3Kα over PI3Kβ, γ and δ, and meanwhile it can remarkable down-regulate the phosphorylation of Akt. In addition, compound I [R = 4-benzhydrylpiperazin-1-ylmethyl] was found to induce cell apoptosis via upregulation of Bax and cleaved-caspase 3/9, and downregulation of Bcl-2. The above results suggested that compound I [R = 4-benzhydrylpiperazin-1-ylmethyl] could be considered as a promising PI3Kα inhibitor.
Safety of N-(2-Hydroxyethyl)piperazine, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics