Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Recommanded Product: N-(2-Hydroxyethyl)piperazine.
Yang, Jie;Cao, Chaoguo;Luo, Dan;Lan, Suke;Luo, Meng;Shan, Huifang;Ma, Xinyu;Liu, Yuanyuan;Yu, Su;Zhong, Xinxin;Li, Rui research published 《 Discovery of 4-(3,5-dimethoxy-4-(((4-methoxyphenethyl)amino)methyl)phenoxy)-N-phenylaniline as a novel c-myc inhibitor against colorectal cancer in vitro and in vivo》, the research content is summarized as follows. Proto-oncogene c-Myc plays an essential role in the development of colorectal cancer (CRC), since downregulation of c-Myc inhibits intestinal polyposis, which is the most cardinal pathol. change in the development of CRC. Herein, a series of novel phenoxy-N-phenylaniline derivatives I (R1 = R2 = R3 = R4 = H; R1 = R2 = R4 = OMe; R5 = N(Me)2, NHCH2C6H5, NH(CH2)2C6H5, etc.) and II (R = 4-MeOC6H4(CH2)2NH, 3-MeOC6H4(CH2)2NH, 2-MeOC6H4(CH2)2NH, 4-MeOC6H4(CH2)3NH) were designed and synthesized. The cytotoxicity activities of all the derivatives were measured by MTT assay in different colon cancer cells, compound II (R = 4-MeOC6H4(CH2)2NH) was discovered, as the lead compound with excellent cytotoxicity activity of IC50 = 0.32μM, IC50 = 0.51μM, in HT29 and HCT 15 cells, resp. Compound II (R = 4-MeOC6H4(CH2)2NH) had a good inhibitory activity of c-Myc/MAX dimerization and DNA binding. Besides, compound II (R = 4-MeOC6H4(CH2)2NH) could effectively induce apoptosis and induced G2/M arrest in low concentration and G0/G1 arrest in high concentration to prevent the proliferation and differentiation in colon cancer cells. Western blot anal. confirmed the compound II (R = 4-MeOC6H4(CH2)2NH) strongly down-regulated expression of c-Myc. Furthermore, during 30 days treatment compound II (R = 4-MeOC6H4(CH2)2NH) exhibited excellent efficacy in HT29 tumor xenograft model without causing significant weight loss and toxicity. Consequently, compound II (R = 4-MeOC6H4(CH2)2NH) could be a promising drug candidate for CRC therapy.
Recommanded Product: N-(2-Hydroxyethyl)piperazine, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics