The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Application In Synthesis of 103-76-4.
Yadav, Lalit;Tiwari, Mohit K.;Shyamlal, Bharti Rajesh Kumar;Chaudhary, Sandeep research published 《 Organocatalyst in Direct C(sp2)-H Arylation of Unactivated Arenes: [1-(2-Hydroxyethyl)-piperazine]-Catalyzed Inter-/Intra-molecular C-H Bond Activation》, the research content is summarized as follows. In the presence of 10 mol% 1-piperazineethanol, aryl iodides and bromides underwent arylation with benzene mediated by KOt-Bu to yield biaryls. N-Aryl 2-bromobenzamides underwent cyclization mediated by KOt-Bu in the presence of 40 mol% 1-piperazineethanol and 40 mol% 4-dimethylaminopyridine in mesitylene to yield phenanthridinones. Study of the reaction mechanism using kinetics and kinetic isotope effects and inhibition studies are consistent with the formation of aryl radical anions and a single electron transfer mechanism.
Application In Synthesis of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics