Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Application In Synthesis of 103-76-4.
Xie, Lan;Goto, Masuo;Chen, Xiaoyan;Morris-Natschke, Susan L.;Lee, Kuo-Hsiung research published 《 Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents》, the research content is summarized as follows. Phenanthrene-based tylophorine-1 (PBT-1) I (R = CH2OH, NHBoc, Me, SO2Me, etc.; R1 = H, OMe; R2 = OH, OMe, OAc, prop-2-yn-1-yloxidanyl, etc.; X = CH, N) and II (R3 = H, OMe; R4 = H, OMe) was identified previously as a lead compound in an anticancer drug discovery effort based on natural Tylophora alkaloids. An expanded structural optimization using a new more efficient synthetic route provided 14 PBT-derivatives I and II. Eleven compounds displayed obvious antiproliferative activities in cellular assays (GI50 0.55-9.32μM). The most potent compounds I (R = CH2OH, R1 = H, R2 = OH, X = CH; R = NHBoc, R1 = H, R2 = OH, X = CH; R = NH2, R1 = H, R2 = OH, X = CH) (GI50 ; 1μM) contained a 7-hydroxy group on the phenanthrene B-ring in addition to a pendant piperidine E-ring with different 4-substituents. While I (R = NH2, R1 = H, R2 = OH, X = CH) with NH2 as the piperidine substituent was at least 4-fold more potent against triple-neg. breast cancer MDA-MB-231 than estrogen-responsible breast cancer MCF-7 cell growth. In further biol. evaluations, the new active compounds induced cell cycle accumulation in late S and G2/M phase without interfering with microtubule formation or cell morphol. These results on the optimization of the B- and E-rings of PBT-1 I and II should benefit the further development of novel antitumor agents.
Application In Synthesis of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics