The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Category: piperazines.
Xi, Jiayue;Yao, Lin;Zhang, Ruyue;Chen, Ke;Li, Muqiong;Zhang, Dongxu;Cui, Minxuan;Nie, Huifang;Wang, Pingan;Li, Xiaoye;Jiang, Ru research published 《 Derivatives of 2-Oxy-3-phenylacrylic acid as potent Mcl-1 inhibitors for treatment of cancer》, the research content is summarized as follows. Myeloid cell leukemia-1 (Mcl-1) is a crucial member of Bcl-2 family protein and is recognized as a promising therapeutic target for cancer treatment. Here, based on the lead compound we reported earlier, a focused library of analogs was designed, synthesized and evaluated for the inhibitory activity against Mcl-1. 2-oxy-3-phenylacrylic acid derivative II [R1 = 4-phenylphenyl, R2 = Ph, R3 = H], turned out to be the most potent compound with good binding affinity for Mcl-1 and anti-proliferative activities. In addition, the effective inhibition of cell migration, the improvement of apoptosis and the decreased expression of Mcl-1 by compound II [R1 = 4-phenylphenyl, R2 = Ph, R3 = H], as well as the mol. docking elucidated its mechanism of action. Taken together, I [X = O, S; R1 = 4-phenylphenyl, [4-(benzyloxy)phenyl], thiophen-2-yl, R2 = (2-cyanoethyl)(methyl)amino, (2-hydroxyethyl)(methyl)amino, 4-(2-hydroxyethyl)piperazin-1-yl, etc.,] and II [R1 = benzyl, 4-phenylphenyl, R2 = Ph, benzyloxy, R3 = H, benzyloxy] may represent a new class of Mcl-1 inhibitors and deserve further study.
Category: piperazines, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics