Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Quality Control of 103-76-4.
Wu, Yu;Cheung, Chen-Yi;Zhou, Yang;Wang, Zhen;Tu, Zhengchao;Cook, Gregory M.;Lu, Xiaoyun research published 《 Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents》, the research content is summarized as follows. With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and extensive drug-resistant strains (XDR-TB), there is an urgent need to develop novel drugs for the treatment of tuberculosis. Here, the authors designed and synthesized a series of 5-methylpyrimidopyridone analogs I [R1 = NHEt, cyclopropylamino, 4-methylpiperidino, etc., R2 = (3s,5S,7s)-adamant-1-yl, cyclopentyl, cyclohexyl, R3 = 2-Cl, 4-Cl, H, 2-CN, etc.] as potential antitubercular agents. The most potent compound II exhibited a MIC value of 4μM in vitro against Mycobacterium tuberculosis. The antitubercular activities of the synthesized compounds were impacted by the amantadine and 2-chlorophenyl groups, and were enhanced by the presence of 3-methyl(4-dimethylamino)piperidinylphenyl. Mol. modeling and binding studies suggest that PknB is the potential mol. target of 5-methylpyrimidopyridone compounds This study provides insights for the future development of new antimycobacterial agents with novel mechanisms of action.
Quality Control of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics