Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. HPLC of Formula: 103-76-4.
Wang, Zhenwei;Zhang, Yan;Wang, Hai;Wang, Xiaowei;Yu, Zhuangzhuang;Zhao, Liwen research published 《 Synthesis and biological evaluation of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives as novel, potent of ALK5 receptor inhibitors》, the research content is summarized as follows. A novel series of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives I [R = 4-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(trifluoromethyl)anilino, (2,2-difluoro-1,3-benzodioxol-5-yl)amino, [2-(3-cyanoazetidin-1-yl)-4-pyridyl]amino, etc.] was synthesized and identified as transforming growth factor type β receptor I (TGF-β R1, also known as activin-like kinase 5 or ALK5) inhibitors. Among them, compound I [R = 4-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(trifluoromethyl)anilino] inhibited ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, resp. Compound I [R = 4-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(trifluoromethyl)anilino] also showed favorable pharmacokinetic profile and ameliorated hERG inhibition. More importantly, 30 mg/kg oral administration of compound I [R = 4-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(trifluoromethyl)anilino] could significantly induced tumor growth inhibition in CT26 xenograft model without obvious toxicity.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, HPLC of Formula: 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics