Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Quality Control of 103-76-4.
Wang, Xintong;Xiao, Haoran;Wang, Jing;Huang, Zongze;Peng, Geng;Xie, Wenjun;Bian, Xiling;Liu, Huijie;Shi, Cheng;Yang, Taoyi;Li, Xin;Gao, Jian;Meng, Ying;Jiang, Qianchen;Chen, Wei;Hu, Fang;Wei, Ningning;Wang, Xiaowei;Zhang, Liangren;Wang, KeWei;Sun, Qi research published 《 Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors》, the research content is summarized as follows. The design, synthesis, and evaluation of N-(4-(trifluoromethoxy)phenyl)-1,3,5-triazin-2-amine derivatives I [R = 4-Me, 4-F, 3,4-di-F, etc.], II [R1 = 4-Me, 4-MeO, 4-F3C, 4-F3CO, 3-F3CO; R2 = 4-F, 4-MeO, 4-Cl, etc.] and III [R3 = Me, methylamino, prop-1-ynyl, etc.] as a series of novel α7 nAChR pos. allosteric modulators (PAMs). The representative compound III [R3 = methylamino] functioned as a type I PAM with an EC50 of 3.0μM and approx. 38-fold enhancement of α7 current in the presence of agonist acetylcholine (100μM). It specifically enhanced α7 current with high selectivity. Compound III [R3 = methylamino] showed good pharmacokinetic property in mice. I.p. injection of III [R3 = methylamino] (3 mg/kg) exhibited sufficient blood-brain barrier penetration in mice. Furthermore, III [R3 = methylamino] were also rescued the auditory gating deficit in mice with schizophrenia-like behavior. Mol. docking of III [R3 = methylamino] with homopentameric α7 nAChR reveald a new mode of action. These results supported the potential of III [R3 = methylamino] for treatment for schizophrenia and Alzheimer’s disease.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Quality Control of 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics