Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. SDS of cas: 103-76-4.
Syed, Anwarhussaini;Battula, Himabindu;Bobde, Yamini;Patel, Tarun;Ghosh, Balaram;Jayanty, Subbalakshmi research published 《 Design and Development of Distinct Tetracyanoquinodimethane Derivatives Exhibiting Dual Effect of Fluorescence and Anticancer Activity》, the research content is summarized as follows. Tetracyanoquinodimethane (TCNQ) is known to react with primary/secondary amines to generate mono/di-substituted TCNQ derivatives resulting in optical (fluorescence) and non-linear optical characteristics. However, the choice of amine plays a key role in the sequel of certain material attributes. The TCNQ derivatives, specifically obtained by reacting TCNQ with simple & small amine side chains of existing anticancer drugs, emerging in dual effect of fluorescence as well as anticancer activity, is not explored so far and has been still existing as a gap in TCNQ related research. Addnl., mono/di-substituted TCNQ’s owning strong fluorescence in solutions (∼10 to 104 order) than their solids are still lacking and are in need to be generated. In this regard, this study aimed to synthesize straightforward TCNQ derivatives in single step by reacting TCNQ with specific (simple and small) amines being side chains of existing anticancer drugs (a contemporary design approach) and successfully obtained novel mono/di-substituted TCNQ derivatives manifesting dual effect of fluorescence and anticancer activity. In this fashion, the usage of bulky main moiety of an anticancer mol. was avoided, since the aim was not to use the total anticancer drug as such, like in a prodrug preparation, but intended to use the minimal part of an anticancer drug to invent novel TCNQ derivatives as anticancer active fluorophores. Wavelength of maximum emission for all the five potent mols. was within ∼525 nm-696 nm. All compounds showed moderate anticancer activity against different cancer cell lines and IC50 values were in the range of 11 to 49μM, when the synthesized novel compounds were tested in B16F10, MDA-MB-231 and A549 cell lines. Henceforth, this study has emanated in the first generation TCNQ derivatives as organic fluorescent anticancer active mols.
SDS of cas: 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics