Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Product Details of C6H14N2O.
Sun, Xiaona;Wang, Yujin;Lei, Zhichao;Yue, Shasha;Chen, Li;Sun, Jianbo research published 《 Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors》, the research content is summarized as follows. A series of novel 5-hydroxyl-1-azabenzanthrone derivatives I (n = 2,3,4; R1 = R2 = piperidino, morpholino, 1-methylpiperazino, 2-methylpiperindin-1-yl, 4-hydroxyethyl piperazin-1-yl) were designed, synthesized and evaluated as dual binding site acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease (AD). The most effective Compound I (n = 3; R1 = R2 = 2-methylpiperindin-1-yl) showed selective inhibition of acetylcholinesterase (eeAChE IC50 = 0.045μM; eeBuChE IC50 = 19.68μM; SI = 437.33). Most of the compounds showed cytoprotective effects on PC12 cells damaged by hydrogen peroxide, which might be related to their antioxidant activity. Further experiments confirmed that the above compound exhibited anti-apoptotic effects at low concentrations and reduced the relative level of ROS generation in PC12 cells. The expression level of proteins related to antioxidant stress pathway in PC12 cells was relatively increased after administrated with compound I (n = 3; R1 = R2 = 2-methylpiperindin-1-yl), which may be beneficial to delay the progression of the disease and moreover, the compound was evaluated to be safe in vivo and in vitro, and showed good overall pharmacokinetic performance and high bioavailability (Foral = 55.5%). Besides, the above compound showed comparable performance in ameliorating the scopolamine-induced cognition impairment to donepezil and in addition, in vitro BBB permeability experiments confirmed that it had high BBB permeability.
Product Details of C6H14N2O, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics